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Another HIV Vaccine Trial Fails After Large-scale Study

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The only vaccine against HIV being tested nearing the completion of testing trials has proved ineffective, its manufacturer has announced.

Known as Mosaico, the trial was the product of a public-private partnership including the US government and the Janssen Pharmaceuticals.

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HIV is a virus that gradually attacks the immune system, which is our body’s natural defence against illness. AIDS is a syndrome caused by the HIV virus.

The failure of the latest candidate underscores the challenges of designing a vaccine for HIV.

The announcement posted on the Johnson & Johnson’s website noted that the study’s independent Data and Safety Monitoring Board determined that the regimen was not effective in preventing HIV infection compared to the placebo among study participants.

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It also said no safety issues with the vaccine regimen were identified.

In light of the DSMB’s determination, the Mosaico clinical trial will be discontinued, it said.

It noted that participant notifications and further analyses of the data are underway. Throughout the trial, study investigators have ensured that any individuals who contracted HIV received prompt HIV treatment and care.

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“We are disappointed with this outcome and stand in solidarity with the people and communities vulnerable to and affected by HIV,” said the Global Therapeutic Area Head, Vaccines, Janssen Research & Development, LLC, Penny Heaton.

“Though there have been significant advances in prevention since the beginning of the global epidemic, 1.5 million people acquired HIV in 2021 alone, underscoring the high unmet need for new options and why we have long worked to tackle this global health challenge.

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“We remain steadfast in our commitment to advancing innovation in HIV, and we hope the data from Mosaico will provide insights for future efforts to develop a safe and effective vaccine. We are grateful to our Mosaico partners and the study investigators, staff, and participants.”

Recall that in 2020, the United States National Institutes of Health announced the end of its HVTN 702 clinical trial of an HIV vaccine. While no safety concerns were found during the trial, the independent data and safety monitoring board found that the vaccine was ineffective in preventing HIV transmission.

Also, in 2021, an investigational HIV vaccine tested in the “Imbokodo” clinical trial conducted in sub-Saharan Africa posed no safety concerns but did not provide sufficient protection against HIV infection, according to a primary analysis of the study data.

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Meanwhile, Mosaico, a Phase three study of Janssen’s investigational HIV vaccine regimen, began in 2019 and completed vaccinations in October 2022.

The study included approximately 3,900 cisgender men and transgender people who have sex with cisgender men and/or transgender people, who represent groups and populations vulnerable to HIV, at over 50 trial sites in Argentina, Brazil, Italy, Mexico, Peru, Poland, Puerto Rico, Spain, and the United States.

“The study evaluated an investigational vaccine regimen containing a mosaic-based adenovirus serotype 26 vector (Ad26.Mos4.HIV) administered during four vaccination visits over one year. A mix of soluble proteins (Clade C/Mosaic gp140, adjuvanted with aluminum phosphate) was also administered at visits three and four.

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“The Mosaico DSMB analysis, based on the data available to date, indicated that the regimen does not protect against HIV and the study is not expected to meet its primary endpoint. No safety issues with the vaccine regimen were identified. In light of this, the study will be discontinued, and further analyses are underway.

“The DSMB’s determination follows the primary analysis of the Phase 2b Imbokodo study, which was announced in August 2021 and found that a similar investigational HIV vaccine regimen did not provide sufficient protection against HIV in a population of young women in sub-Saharan Africa.

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“The investigational vaccine regimen used in the Imbokodo study was found to have a favorable safety profile,” it added.

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Police Urge Bauchi Residents To Remain Calm Amidst Soldier’s Death In Bauchi

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The Police in Bauchi state has called on all the residents of the state to remain calm after a soldier was shot dead by a police officer in the state.

CSP Ahmed Wakil, the Police Public Relations Officer (PPRO) made the call on behalf of the Commissioner of Police in the state, Sani Omolori-Aliyu.

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According to him, Inter-agency security forces have initiated a thorough investigation into the circumstances surrounding the unfortunate incident which led to the death of the soldier.

The PPRO recalled how a blogger narrated the incident that a member of the Nigerian Army attached to 33 Artillery Brigade was fatally shot while attempting to intercept a truck suspected of transporting solid minerals from an illegal mining site in Futuk, Alkaleri Local Government Area of the state by a mobile police Inspector on illegal duty.

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The blogger also said that the incident occurred on August 25 at about 7:50 p.m. when personnel from the 33 Artillery Brigade, Bauchi, purportedly stopped a truck with the registration number Gombe 676-BLG at a checkpoint in Futuk village.

“The report further added that the truck driver refused to comply, prompting the Guard Commander, Master Warrant Officer, Ali Haruna, now deceased, to pursue the vehicle with his team on motorbikes until they managed to intercept it.

“That upon stopping the truck, Inspector Yusuf Ibrahim, a mobile police officer, exited his vehicle and opened fire on the Guard Commander, striking him in the abdomen.

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“The blogger added that the soldiers at the scene overpowered the policeman and disarmed him. The injured officer was transported to the Gombe Specialist Hospital for urgent medical attention, but tragically succumbed to the gunshot wound,” said the PPRO.

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He however, explained that preliminary investigations, revealed that the truck is associated with Guruje Mining Company Limited and ZURFI Company Limited, which possessed valid legal licenses in Gwana, Alkaleri LGA.

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He said that this authorisation pertained to the extraction of lead and zinc minerals, which was obtained from the Mining Cadastre Office, Federal Republic of Nigeria, effective from 12th May 2023.

Wakil added that the companies have complied with all mining operational protocols of the Nigerian Minerals and Mining Act of 2007 and possessed a certificate of incorporation pursuant to the Companies and Allied Matters Act of 2020.

READ ALSO:Bumper Harvest: Foundation Distributes 6,000 Fertilizers To Farmers In Bauchi

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“The mobile police officers attached to these companies were formally requested and approved to provide security for the safety of expatriate workers and fulfil other security responsibilities associated with the company. Inspector Yusuf Ibrahim was among those assigned to this duty.

“The company successfully extracted a substantial quantity of lead and zinc minerals, which were proposed for export, and relevant fees as revenue paid to the Federal Ministry of Mines and Steel Development, referenced by RRR code 3212-7561-4841.

“The Bauchi state Police command has constituted an investigation team of experienced detectives in collaboration with the Nigerian Army military police and are tasked with collecting and assessing all relevant information surrounding the incident’s remote and immediate causes,” Wakil said.

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How Becoming Bank Manager At 27 Changed My Life, Tony Elumelu Urges Trust In Africa’s Youths

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Prominent African businessman and philanthropist, Tony Elumelu, has reflected on the defining moment of his early career when he was appointed a bank branch manager at just 27 years old.

In a post shared on his LinkedIn page on Tuesday, Elumelu recounted how his appointment at AllStates Trust Bank changed the trajectory of his life and shaped his passion for empowering young people.

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When I was 27, I was given the opportunity of a lifetime: I became a branch manager at AllStates Trust Bank, a young bank in Nigeria.

“Banking was beginning to change the country, it was the sector to be in, ripe for transformation, ready for disruption, for democratisation.

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At that time, few believed a 27-year-old could successfully lead a bank branch. But that opportunity changed the entire course of my life.

“It gave me confidence. It gave me a platform. Most importantly, it gave me perspective,” he wrote.

Elumelu, who is the founder of the Tony Elumelu Foundation and chairs Heirs Holdings and United Bank for Africa, noted that his journey began not with financial capital but with trust.

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His post continued, “That’s why today, I am passionate about giving young people the same chance I was given. Because I know what’s possible when someone believes in you early.

“This belief is at the heart of everything we do at The Tony Elumelu Foundation. It’s why we invest in young African entrepreneurs – because someone once invested in me.

READ ALSO:EFCC Arraigns Bankers, Accomplices For Alleged N8.5bn Fraud

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My journey didn’t begin with capital. It began with trust. Let’s keep believing in Africa’s youth. They are ready to lead, grow and transform our continent.”

In a follow-up post on X on Friday, the business leader further highlighted three lessons from his experience as a young bank manager.

“Shared recently on my LinkedIn page how I became a bank manager at just 27. I got a lot of questions. One stood out: How could someone so young handle such responsibility?

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“Many doubted a young man could lead a bank branch. That chance changed the entire course of my life,” he wrote.

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Outlining the lessons from his journey, Elumelu wrote, “Lesson 1: Age is not a barrier. If you can execute, are hungry to learn, and committed to results — you can lead at any age. Leadership is about clarity of vision and that discipline to execute.

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“Lesson 2: The most powerful capital is trust. My journey didn’t start with money — it started with trust. Trust was the seed that propelled everything else. Give young people trust, and they will surprise you. I was trusted, I repaid that trust.”

In the third lesson, Elumelu explained why perspective matters in leadership.

He wrote, “Leadership is not about doing everything yourself. It is about empowering, setting direction, and providing clarity. The sooner you learn this, the faster you grow.

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That’s why today, I am passionate about giving young people the same chance I was given. Cascading luck. Catalysing opportunity.”

Elumelu said these principles continue to drive his commitment to youth empowerment through his foundation.

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It is the reason we invest in Africa’s youths at the #TonyElumeluFDN, because someone once invested in me,” he wrote.

My story is proof that when we trust in our youths, they are ready to lead, grow, and transform our continent. Let’s keep believing in Africa’s youths,” he concluded.

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Lawyer Sues Sanwo-Olu For Blocking Him On X

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Human rights lawyer, Festus Ogun, has filed a lawsuit against Lagos State Governor, Babajide Sanwo-Olu, at the Federal High Court in Lagos for allegedly violating his fundamental rights by blocking him on his verified X (formerly Twitter) account.

In the suit marked FHC/L/CS/1739/25, which was shared by Ogun on Friday via his facebook page, he said the governor’s decision to block him since 2021 was triggered by his “constructive criticisms” and “demand for accountability” over the October 2020 #EndSARS killings.

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In 2021, I noticed that the Governor blocked me on his official X handle @jidesanwoolu owing to my constructive criticisms of his policies and demand for accountability in respect of the October 2020 #EndSARS Massacre,” Ogun wrote.

According to him, being blocked has deprived him of access to vital information.

READ ALSO:DSS Charges Nine Over Benue, Plateau Massacres

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“Blocking me on X has prevented me from accessing public updates and receiving information about policies and governance in Lagos, which constitutes a violation of my right to receive information without interference,” he said.

In his originating summons cited by The PUNCH, the lawyer asked the court to declare the action unconstitutional, arbitrary, and discriminatory.

According to the lawsuit, Ogun said he sought “a declaration that, as a democratically-elected public office holder in Nigeria, the Respondent (@jidesanwoolu)’s blocking of the Applicant (@mrfestusogun), a citizen of Nigeria and resident of Lagos State, on X (formerly ‘Twitter’) is wrongful, unconstitutional, arbitrary and constitutes a gross.”

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He further prayed the court to compel Sanwo-Olu to unblock him, issue a public apology, and stop targeting critics online.

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An order of perpetual injunction restraining the Respondent, his agents, privies or any other person or entity acting through or on his behalf, from further blocking the Applicant on X or any other social media platform,” the suit read.

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Ogun, who described himself as “haunted, traumatised and emotionally disturbed,” stressed that the matter went beyond his personal grievance. “This suit is not just about me. I have filed this lawsuit in furtherance of public interest and with the hope that it sets a precedent in our digital rights jurisprudence,” he said.

The lawyer also invited the court to take guidance from a 2019 ruling in the United States.

I invited the Nigerian court to be persuaded by the decision of the US District Court in Knight First Amendment Institute v Trump where President Trump was found to be in violation of the 1st Amendment when he blocked US citizens for criticising him on Twitter,” he stated.

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Ogun argued that intolerance to opposing views undermines democracy. “Intolerance to criticism and accountability is unconstitutional and undemocratic. Nigerian authorities continue to crack down on dissents, critics, journalists, bloggers and vocal citizens on social media using arrests, detention, surveillance, collusion with big techs and outright blocking, as weapons. That narrative must stop,” he warned.

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