Connect with us

News

Another HIV Vaccine Trial Fails After Large-scale Study

Published

on

The only vaccine against HIV being tested nearing the completion of testing trials has proved ineffective, its manufacturer has announced.

Known as Mosaico, the trial was the product of a public-private partnership including the US government and the Janssen Pharmaceuticals.

Advertisement

HIV is a virus that gradually attacks the immune system, which is our body’s natural defence against illness. AIDS is a syndrome caused by the HIV virus.

The failure of the latest candidate underscores the challenges of designing a vaccine for HIV.

The announcement posted on the Johnson & Johnson’s website noted that the study’s independent Data and Safety Monitoring Board determined that the regimen was not effective in preventing HIV infection compared to the placebo among study participants.

Advertisement

It also said no safety issues with the vaccine regimen were identified.

In light of the DSMB’s determination, the Mosaico clinical trial will be discontinued, it said.

It noted that participant notifications and further analyses of the data are underway. Throughout the trial, study investigators have ensured that any individuals who contracted HIV received prompt HIV treatment and care.

Advertisement

READ ALSO: FG Okays Salary Increase For Port Workers

“We are disappointed with this outcome and stand in solidarity with the people and communities vulnerable to and affected by HIV,” said the Global Therapeutic Area Head, Vaccines, Janssen Research & Development, LLC, Penny Heaton.

“Though there have been significant advances in prevention since the beginning of the global epidemic, 1.5 million people acquired HIV in 2021 alone, underscoring the high unmet need for new options and why we have long worked to tackle this global health challenge.

Advertisement

“We remain steadfast in our commitment to advancing innovation in HIV, and we hope the data from Mosaico will provide insights for future efforts to develop a safe and effective vaccine. We are grateful to our Mosaico partners and the study investigators, staff, and participants.”

Recall that in 2020, the United States National Institutes of Health announced the end of its HVTN 702 clinical trial of an HIV vaccine. While no safety concerns were found during the trial, the independent data and safety monitoring board found that the vaccine was ineffective in preventing HIV transmission.

Also, in 2021, an investigational HIV vaccine tested in the “Imbokodo” clinical trial conducted in sub-Saharan Africa posed no safety concerns but did not provide sufficient protection against HIV infection, according to a primary analysis of the study data.

Advertisement

Meanwhile, Mosaico, a Phase three study of Janssen’s investigational HIV vaccine regimen, began in 2019 and completed vaccinations in October 2022.

The study included approximately 3,900 cisgender men and transgender people who have sex with cisgender men and/or transgender people, who represent groups and populations vulnerable to HIV, at over 50 trial sites in Argentina, Brazil, Italy, Mexico, Peru, Poland, Puerto Rico, Spain, and the United States.

“The study evaluated an investigational vaccine regimen containing a mosaic-based adenovirus serotype 26 vector (Ad26.Mos4.HIV) administered during four vaccination visits over one year. A mix of soluble proteins (Clade C/Mosaic gp140, adjuvanted with aluminum phosphate) was also administered at visits three and four.

Advertisement

READ ALSO: WHO To Establish TB Vaccine Accelerator Council

“The Mosaico DSMB analysis, based on the data available to date, indicated that the regimen does not protect against HIV and the study is not expected to meet its primary endpoint. No safety issues with the vaccine regimen were identified. In light of this, the study will be discontinued, and further analyses are underway.

“The DSMB’s determination follows the primary analysis of the Phase 2b Imbokodo study, which was announced in August 2021 and found that a similar investigational HIV vaccine regimen did not provide sufficient protection against HIV in a population of young women in sub-Saharan Africa.

Advertisement

“The investigational vaccine regimen used in the Imbokodo study was found to have a favorable safety profile,” it added.

Advertisement

News

Full List Of Schengen Countries Offering 5-yr Visa Programme

Published

on

By

Nigerians with a strong travel history now have more incentive to explore European countries, thanks to the five-year multiple entry Schengen visa.

This long-term visa offers travelers the freedom to enter any of the 29 Schengen countries multiple times over five years: provided no stay exceeds 90 days within any 180-day window.

Advertisement

Designed primarily for frequent travelers, business professionals, and individuals with consistent international travel records, the visa eliminates the hassle of reapplying for short-term permits.

It reduces visa processing time, lowers application costs, and simplifies the documentation and interview requirements.

Approval for the five-year visa is still subject to the discretion of the issuing embassy or consulate.

Advertisement

READ ALSO:US Visa Adjudication Sparks Concerns Over Diplomatic Relations

However, applicants with a higher likelihood of success typically meet one or more of the following criteria:

Previously held a multiple entry Schengen visa valid for at least two years within the past three years

Advertisement

Travel to Schengen countries at least two to three times a year

Demonstrated compliance with visa regulations, including no overstays and proper documentation

To boost their chances, applicants are expected to submit a compelling cover letter stating the purpose and need for long-term travel, show proof of financial stability, and provide valid long-term Schengen travel insurance.

Advertisement

READ ALSO:10 Countries Hiring Nigerians, Other Foreign Workers In 2025 With Easy Visa Process

Eligible Countries under the Five-Year Schengen Visa
Holders of this visa can travel freely to the following 29 Schengen member states:

Austria
Belgium
Bulgaria
Croatia
Czech Republic
Denmark
Estonia
Finland
France
Germany
Greece
Hungary
Iceland
Italy
Latvia
Liechtenstein
Lithuania
Luxembourg
Malta
Netherlands
Norway
Poland
Portugal
Romania
Slovakia
Slovenia
Spain
Sweden
Switzerland

Advertisement

Continue Reading

News

Aburi Accord: Foreign Powers Fueled Nigeria’s Civil War, Elder Statesman Replies Gowon

Published

on

By

Elder statesman and president of the Osisioma Foundation, Dr. Chike Obidigbo, has highlighted the role of foreign powers, particularly Britain and certain corporate interests, in Nigeria’s civil war (1967–1970).

In a statement on Thursday, Obidigbo called on former Head of State, Retired General Yakubu Gowon, to use his remaining years to share the truth about the war and promote national healing.

Advertisement

The statement, issued by the Osisioma Foundation, responded to Gowon’s recent public comments about the failed Aburi Accord and the civil war, which Obidigbo described as inconsistent. He stressed the need for clarity on historical events to help promote national reconciliation.

Obidigbo noted that the collapse of the Aburi Accord, a key peace agreement, was influenced by external forces.

READ ALSO:Why Aburi Accord Collapsed – Gowon

Advertisement

Though Gowon may not have wanted the war, forces beyond him, particularly British and Fulani interests, compelled him to plunge the country into conflict,” he stated.

He also revealed that Britain and Shell Petroleum had made secret offers to Lt. Colonel Emeka Odumegwu Ojukwu, the then-leader of the Eastern Region, to secede from Nigeria.

Britain assured Ojukwu that they would talk Nigeria out of any plan to fight Biafra if Ojukwu agreed to secede. They even promised to pay him the huge arrears of royalties from Shell in case of any eventuality,” Obidigbo disclosed.

Advertisement

He stressed the importance of historical accountability, saying, “At his age, Gowon should be telling Nigerians the truth and nothing but the truth about the war. Until he makes these facts known through public confession, his soul may not experience peace.”

READ ALSO:Biafra Civil War: You’re A Genocidist – IPOB Fires Back At Gowon

Drawing parallels with contemporary global issues, Obidigbo stated, “It is ironic that the same British that caused total genocide and blockade against Biafra are now crying out that Israel is visiting genocide on Palestinians.”

Advertisement

He urged Gowon to document his experiences honestly, following the example of former Military President Ibrahim Babangida, who recently released his autobiography.

Instead of reopening old wounds, Gowon should use his remaining days to contribute to a truthful historical record that fosters national unity,” Obidigbo advised.

The elder statesman called for national reconciliation, urging leaders to prioritize peace and unity.

Advertisement

Nigerians need to hear the truth about what transpired so that we can heal and move forward as a nation,” he said.

Advertisement
Continue Reading

News

Poly Ibadan: Mixed Reactions Trail Renaming, Alumni Kick

Published

on

By

Mixed reactions have trailed Thursday’s renaming of The Polytechnic Ibadan, with the institution’s alumni largely calling for a review.

The respondents expressed their diverse views in separate interviews with the News Agency of Nigeria (NAN) in Ibadan, with members of the alumni frowning at the change of name.

Advertisement

Recall that Gov. Seyi Makinde announced the institution’s renaming after the late ex-governor of Oyo State, Dr Omololu Olunloyo, during the deceased’s commendation service in Ibadan.

Mr Yomi Akande, an alumnus and the institute’s Non-Academic Staff Union (NASU) leader, said many other alumni had been expressing dissatisfaction since the announcement.

“As an alumnus of The Polytechnic Ibadan, the name of the institution is a force to reckon with anywhere in the world.

Advertisement

“So, taking away that name is somehow because of the prestige that comes with it.

“The governor needed to have considered other factors before making such a pronouncement.

READ ALSO: JUST IN: Oyo Ex-governor, Olunloyo, Is Dead

Advertisement

“The name of the late Dr Omololu Olunloyo is good, but what many people are against is the changing of the name, The Polytechnic Ibadan.

“It is not that the change of name will bring new development to the school,” he said.

Another alumnus, Mr Olaoluwa Olabode, said that the renaming would affect both past and current students negatively.

Advertisement

According to him, he doesn’t see the move bringing any improvement to the educational institution, alleging that it was done with a political undertone.

What benefits would the change of name bring to the school?” Olabode queried.

In his opinion, another alumnus, Mr Sanmi Olatunde, said perhaps the government should have renamed a particular building in the school instead of the institution’s name.

Advertisement

READ ALSO: Trade Volume Between Vietnam, Nigeria Surpasses $1bn – Envoy

This is the only polytechnic we have in Ibadan; it is not right that the name of the institution is changed,” Olatunde said.

Calling for a review, an Ibadan indigene and alumnus, Mr Tayo Olaleye, described the institution as the pride of the ancient city of Ibadan that should not be tampered with.

Advertisement

According to him, it is not acceptable for the name to be changed at will.

Furthermore, Olaleye said the renaming would affect the students in easily securing favour and job opportunities with the alumni.

This is a prestigious institution whose name has been resounding in many spheres for decades, at home and abroad, so we do not welcome the sudden renaming,” Olaleye said.

Advertisement

Meanwhile, Comrade Tiamiyu Ademola, Chairman, National Association of Nigerian Students (NANS), Joint Campus Committee (JCC), Oyo State Chapter, said the renaming would not affect the institution’s reputation.

According to him, the institution’s reputation will stand provided its management maintains its standard.

He also urged the students not to allow the matter to lead to any form of protest.

Advertisement

READ ALSO: Olunloyo: Goodnight, Voltaire

However, he noted that the decision could still be reversed with genuine arguments from alumni and other stakeholders of the institution.

We believe that Gov. Seyi Makinde is a listening governor; with the right approach, I believe the decision can still be reversed,” he said.

Advertisement

However, a chieftain of the Peoples Democratic Party (PDP), Alhaji Moshood Olaleke, hailed Makinde for honouring Olunloyo with the gesture.

Olaleke said no honour would be too great for Olunloyo, whom he referred to as a great mathematician.

He described the three months Olunloyo spent as the executive governor of the old Oyo State before the military took over as remarkable.

Advertisement

According to him, Olunloyo had already put in place a solid structure for good governance before the coup that terminated his tenure.

He said that Makinde should be commended for recognising the positive contributions of the late technocrat to the state.

Recall that Olunloyo died on April 6, a few days before April 14, when he would have turned 90 years old.
(NAN)

Advertisement

Continue Reading

Trending

Exit mobile version