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Pig Kidney Functioning In Human For More Than A Month

Published

2 years ago

August 16, 2023

A genetically-modified pig kidney is continuing to function well a record-breaking 32 days after it was transplanted into a brain dead patient, a medical center said Wednesday.

The experimental procedure is part of a growing field of research aimed at advancing cross-species organ donation and thus reducing transplant waiting lists.

There are more than 103,000 people waiting for transplants in the United States, 88,000 of whom need kidneys.

“This work demonstrates a pig kidney -— with only one genetic modification and without experimental medications or devices — can replace the function of a human kidney for at least 32 days without being rejected,” said surgeon Robert Montgomery, director of the NYU Langone Transplant Institute.

Montgomery carried out the first genetically modified pig kidney transplant to a human in September 2021, followed by a similar procedure in November 2021. There have since been a handful of other cases.

While previous such transplants have involved up to 10 modifications, the latest experiment involved just one: the gene involved in the so-called “hyperacute rejection,” which would otherwise occur within minutes of an animal organ being connected to a human circulatory system.

By “knocking out” the gene responsible for a biomolecule called alpha-gal — which otherwise would be a prime target for human antibodies — the NYU Langone team were able to stop immediate rejection.

“We’ve now gathered more evidence to show that, at least in kidneys, just eliminating the gene that triggers a hyperacute rejection may be enough along with clinically approved immunosuppressive drugs to successfully manage the transplant in a human for optimal performance—potentially in the long-term,” said Montgomery.

They also embedded the pig’s thymus gland — responsible for educating the immune system — in the kidney’s outer layer, in order to prevent a more delayed host rejection.

Both of the patient’s own kidneys were removed, then one pig kidney was transplanted, and started immediately producing urine.

Monitoring showed that levels of creatinine, a waste product, were at optimal levels, and there was no evidence of rejection.

Crucially, no evidence of porcine cytomegalovirus — which may trigger organ failure — have been detected, and the team plan to continue monitoring for another month.

The research was made possible by the family of the 57-year-old male patient who had elected to make his body available for science.

In January 2022, surgeons at the University of Maryland Medical School carried out the world’s first pig-to-human transplant on a living patient. He died two months after the milestone, with the presence of porcine cytomegalovirus in the organ later blamed for his death.

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Mexican President Pledges Tougher Sexual‑harassment Laws After Being Groped

Published

3 days ago

November 6, 2025

Editor

Mexican President Claudia Sheinbaum on Thursday unveiled proposals to boost reporting and prosecution of sexual abuse after she herself was groped in the street in an attack that caused outrage.

Mexico’s first woman president, 63, was assaulted on Tuesday by a drunken man while walking through the streets of the capital.

The assault made global headlines and focused attention on the dangers and harassment suffered by many women in the Latin American country.

Sheinbaum has pressed charges against her attacker for sexual harassment, a charge that in Mexico City covers lewd behaviour and groping.

She has also ordered a review of the widely diverging laws on sexual harassment and abuse across Mexico’s 32 states.

Sexual harassment in public spaces is so prevalent in Mexico that in the last decade, the authorities have created women-only spaces on the metro.

Other cities with similar arrangements include Mumbai and Rio.

“May what happened serve so that women do not feel alone in situations of harassment or abuse… and for this to happen, there must be institutions and a government that supports them,” Sheinbaum told her regular morning press conference.

The UN says around 70 per cent of Mexican girls and women aged 15 and over will experience at least one incident of sexual harassment in their lives.

Sheinbaum said that 45 per cent had experienced sexual “abuse.”

The man who assaulted her put one arm around her shoulder while she was greeting supporters, and with his other hand touched her hip and chest while attempting to kiss her neck.

A member of Sheinbaum’s security detail pulled him away.

Citlalli Hernandez, Secretary for Women, said more than 25,000 complaints of sexual harassment have been filed so far this year.

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US Lawmakers Urge Sanctions On Miyetti Allah, Others Over Alleged Religious Violations

Published

3 days ago

November 6, 2025

Editor

The United States House of Representatives has urged the Departments of State and Treasury to impose targeted sanctions on individuals and organisations, including Miyetti Allah Cattle Breeders Association of Nigeria and Miyetti Allah Kautal Hore, over alleged violations of religious freedom in Nigeria.

This was contained in a resolution introduced before the House on Tuesday and cited by The PUNCH from the US Congress website on Wednesday.

Recall that Trump, in a post on Truth over the weekend, declared Nigeria a “Country of Particular Concern” and threatened to take military action if the country did not stem the alleged killings of Christians.

Filed as H. Res. 860 in the 119th Congress, the resolution, submitted by Rep. Christopher Smith with Rep. Paul Huizenga as a co-sponsor, commends President Donald Trump for redesignating Nigeria as a CPC.

The sponsors decried the alleged worsening persecution of Christians and other religious minorities.

They cited a catalogue of findings and reports that informed the measure, including media accounts and NGO data alleging large-scale attacks on civilians, destruction of places of worship, and a pattern of impunity.

The resolution reads in parts, “For over a decade, Islamic terror organisations have carried out mass murder, rape, kidnappings, and other atrocities targeting mostly Nigerian Christians and non-Fulani moderate Muslim populations, resulting in mass displacement and destruction of places of worship

“Prominent Christian and Muslim leaders have been kidnapped or assassinated, including priests, pastors, and imams who advocate for religious tolerance;

“Religious leaders, such as Father Remigius Iyhula and Bishop Wilfred Anagbe, who testified on March 12, 2025, at a hearing of the House Foreign Affairs Committee about the persecution and targeted killings of Christians in the Diocese of Makurdi, have faced intimidation, threats, and harassment from both extremist groups and government authorities.”

Supporters of the measure argued that the CPC redesignation would strengthen diplomatic leverage to press Nigeria for accountability and protection of religious minorities.

“The designation of Nigeria as a CPC will enhance diplomatic efforts to encourage the Nigerian government to take necessary actions to protect religious minorities and uphold fundamental human rights,” they said.

They therefore moved that “President Donald Trump acted appropriately and decisively to redesignate Nigeria as a CPC and hold the Nigerian government accountable for its complicity in religious persecution by radical Islamists, such as Boko Haram and Fulani terrorists.”

They further recommended conditioning US foreign assistance on demonstrable steps by Nigeria to prevent persecution, prosecute alleged perpetrators, and care for displaced populations.

“The State Department should provide immediate humanitarian assistance directly to faith-based groups to support internally displaced people in Nigeria’s middle belt states.

“The United States, through the Department of State and Department of Treasury, should impose targeted sanctions, including visa bans and asset freezes under the Global Magnitsky framework and other restrictive measures, on individuals and entities responsible for severe violations of religious freedom in Nigeria, including sanctions against Miyetti Allah Cattle Breeders Association of Nigeria (MACBAN) and Miyetti Allah Kautal Hore, and should place Fulani-Ethnic Militias operating in Benue and Plateau States on the Entities of Particular Concern List under the International Religious Freedom Act,” the resolution read.

The resolution also asked the US to justify the purposes and amounts of recent security and development assistance to Nigeria and to tie future support to improved human-rights outcomes.

The resolution was referred to the House Foreign Affairs Committee and the Judiciary Committee for further consideration.

If it advances out of committee, the resolution would mark a clear congressional signal backing Trump’s CPC decision and could open the door to further legislative or executive actions.

Meanwhile, the Federal Government had said the United States’ designation of Nigeria as a “country of particular concern” over alleged violations of religious freedom is based on a wrong perception of the country’s security challenges.

The Minister of Information and National Orientation, Mohammed Idris, stated this on Wednesday in Abuja while addressing journalists.

Idris said the US position stemmed from “misrepresentation and misinformation” about Nigeria’s internal security situation.

According to him, terrorism and violent crimes in Nigeria do not target any particular religious group.

“Nigeria faces long-standing security challenges that have impacted Christians and Muslims alike.

“Any narrative suggesting that the Nigerian state is failing to take action against religious attacks is based on misinformation or faulty data,” Idris said.

Headline

Nancy Pelosi, First Female Speaker Of US House, Announces Retirement

Published

3 days ago

November 6, 2025

Editor

Nancy Pelosi, a towering figure in US politics and the first woman to serve as speaker of the House of Representatives, announced on Thursday that she will step down at the next election.

“I will not be seeking reelection to Congress,” said the 85-year-old Democrat who has been one of President Donald Trump’s fiercest opponents.

In a video targeted at her hometown constituents in San Francisco, Pelosi said that she would serve her final year “with a grateful heart.”

Pelosi — whose term ends in January 2027 — was the first woman to lead a major political party in the US Congress.

Despite entering political office later in life, she quickly rose through the ranks to become a darling of liberal West Coast politics and, eventually, one of the most powerful women in US history.

She is in her 19th term and has represented her San Francisco-area district for 38 years. But her fame centers especially on her renowned skills at the national level, leading her party for two decades.

As House speaker for eight years, she was second in line to the presidency, after the vice president, including during Trump’s chaotic first term.

She was revered for her ability to corral her often fractious caucus through difficult votes, including Barack Obama’s signature Affordable Care Act and Joe Biden’s infrastructure programs.

Republicans painted her as the driving force behind a liberal elite that had turned its back on American values and was undermining the social fabric.

Trump especially made her a target, repeatedly insulting her as “crazy Nancy.” Pelosi never shrank from direct confrontations with the Republican leader, including demonstratively ripping up a copy of his State of the Union speech on live television.

Rumors of her departure had been swirling for weeks on Capitol Hill, but she deflected questions over her political future, insisting that she was focused on a redistricting reform initiative in California that passed on Tuesday.

“I say to my colleagues in the House all the time, no matter what title they have bestowed upon me — speaker, leader, whip — there has been no greater honor for me than to stand on the House floor and say, I speak for the people of San Francisco,” Pelosi said.

“I have truly loved serving as your voice,” she said. “As we go forward, my message to the city I love is this: San Francisco, know your power.”