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Pig Kidney Functioning In Human For More Than A Month

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A genetically-modified pig kidney is continuing to function well a record-breaking 32 days after it was transplanted into a brain dead patient, a medical center said Wednesday.

The experimental procedure is part of a growing field of research aimed at advancing cross-species organ donation and thus reducing transplant waiting lists.

There are more than 103,000 people waiting for transplants in the United States, 88,000 of whom need kidneys.

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“This work demonstrates a pig kidney -— with only one genetic modification and without experimental medications or devices — can replace the function of a human kidney for at least 32 days without being rejected,” said surgeon Robert Montgomery, director of the NYU Langone Transplant Institute.

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Montgomery carried out the first genetically modified pig kidney transplant to a human in September 2021, followed by a similar procedure in November 2021. There have since been a handful of other cases.

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While previous such transplants have involved up to 10 modifications, the latest experiment involved just one: the gene involved in the so-called “hyperacute rejection,” which would otherwise occur within minutes of an animal organ being connected to a human circulatory system.

By “knocking out” the gene responsible for a biomolecule called alpha-gal — which otherwise would be a prime target for human antibodies — the NYU Langone team were able to stop immediate rejection.

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We’ve now gathered more evidence to show that, at least in kidneys, just eliminating the gene that triggers a hyperacute rejection may be enough along with clinically approved immunosuppressive drugs to successfully manage the transplant in a human for optimal performance—potentially in the long-term,” said Montgomery.

They also embedded the pig’s thymus gland — responsible for educating the immune system — in the kidney’s outer layer, in order to prevent a more delayed host rejection.

Both of the patient’s own kidneys were removed, then one pig kidney was transplanted, and started immediately producing urine.

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Monitoring showed that levels of creatinine, a waste product, were at optimal levels, and there was no evidence of rejection.

Crucially, no evidence of porcine cytomegalovirus — which may trigger organ failure — have been detected, and the team plan to continue monitoring for another month.

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The research was made possible by the family of the 57-year-old male patient who had elected to make his body available for science.

In January 2022, surgeons at the University of Maryland Medical School carried out the world’s first pig-to-human transplant on a living patient. He died two months after the milestone, with the presence of porcine cytomegalovirus in the organ later blamed for his death.

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Indian Court Denies Bail To Nigerian Man Over Drug Charges

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A court in India has denied bail to a 44-year-old Nigerian national, Cristian Soporuchukwu, who is currently facing drug trafficking charges in the country.

Cristian Soporuchukwu initially entered India on a business visa but was later arrested over allegations of involvement in the sale of hard drugs.

Reports indicated that after arriving in India, Soporuchukwu travelled through Goa, Delhi, and Mumbai, where he allegedly established links with suspected drug traffickers.

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He was accused of purchasing MDMA crystals and distributing them to college students and information technology workers.

According to reports, operatives of the Beguru Police arrested Cristian Soporuchukwu in April 2025 for allegedly selling MDMA crystals around Begur Lake and the AECS Layout Road area.

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The New Indian Express reported that the High Court of Karnataka subsequently dismissed the Nigerian’s bail application.

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“The anti-narcotics wing seized about 1 kg of MDMA crystals, a pocket weighing machine, 10 zip-lock covers, a mobile phone and a scooter from him,” the report stated.

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Justice V. Srishananda, while ruling on the bail application, reportedly held that errors relating to the grounds of arrest could not automatically justify bail in serious narcotics-related offences under the Narcotic Drugs and Psychotropic Substances, NDPS, Act.

The court further noted that Cristian Soporuchukwu had allegedly overstayed his visa in India, according to the report.

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Strait Of Hormuz: US Announces Sanctions Against Iran

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The United States Treasury has announced sanctions against Iran’s Persian Gulf Strait Authority.

Treasury Secretary, Scott Bessent, said this in a statement on Wednesday.

The statement extended the threat of sanctions to anyone paying the fees, saying they may be providing support to and receiving services from Iran’s Revolutionary Guards, and therefore may be exposed to sanctions risk.

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“The Iranian military’s latest attempt to extort global maritime trade is proof that Economic Fury has left the regime desperate for cash.

“Treasury has deprived the Iranian regime of revenue for their weapons programs, terrorist proxies, and nuclear ambitions,” Bessent said.

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Bessent added that the US has succeeded in disrupting tens of billions of dollars’ worth of revenue from being accessible to Tehran.

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US Launches New Airstrikes On Iran

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The United States has launched new airstrikes in southern Iran.

The strike shot down four one-way attack drones that posed a threat around the Strait of Hormuz and then a ground control site.

A US official revealed that American forces struck an Iranian ground control station in Bandar Abbas that was about to launch a fifth drone.

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The official described the strikes as purely defensive, saying the US intended to maintain the ceasefire.

Report says this is the second time in three days that the US has carried out self-defense strikes against Iranian military targets in southern Iran.

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Recall that on Monday the US carried out airstrikes against Iranian missile locations and boats that US Central Command said were preparing to launch mines in the Strait of Hormuz.

 

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