Headline
Pig Kidney Functioning In Human For More Than A Month

A genetically-modified pig kidney is continuing to function well a record-breaking 32 days after it was transplanted into a brain dead patient, a medical center said Wednesday.
The experimental procedure is part of a growing field of research aimed at advancing cross-species organ donation and thus reducing transplant waiting lists.
There are more than 103,000 people waiting for transplants in the United States, 88,000 of whom need kidneys.
“This work demonstrates a pig kidney -— with only one genetic modification and without experimental medications or devices — can replace the function of a human kidney for at least 32 days without being rejected,” said surgeon Robert Montgomery, director of the NYU Langone Transplant Institute.
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Montgomery carried out the first genetically modified pig kidney transplant to a human in September 2021, followed by a similar procedure in November 2021. There have since been a handful of other cases.
While previous such transplants have involved up to 10 modifications, the latest experiment involved just one: the gene involved in the so-called “hyperacute rejection,” which would otherwise occur within minutes of an animal organ being connected to a human circulatory system.
By “knocking out” the gene responsible for a biomolecule called alpha-gal — which otherwise would be a prime target for human antibodies — the NYU Langone team were able to stop immediate rejection.
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“We’ve now gathered more evidence to show that, at least in kidneys, just eliminating the gene that triggers a hyperacute rejection may be enough along with clinically approved immunosuppressive drugs to successfully manage the transplant in a human for optimal performance—potentially in the long-term,” said Montgomery.
They also embedded the pig’s thymus gland — responsible for educating the immune system — in the kidney’s outer layer, in order to prevent a more delayed host rejection.
Both of the patient’s own kidneys were removed, then one pig kidney was transplanted, and started immediately producing urine.
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Monitoring showed that levels of creatinine, a waste product, were at optimal levels, and there was no evidence of rejection.
Crucially, no evidence of porcine cytomegalovirus — which may trigger organ failure — have been detected, and the team plan to continue monitoring for another month.
The research was made possible by the family of the 57-year-old male patient who had elected to make his body available for science.
In January 2022, surgeons at the University of Maryland Medical School carried out the world’s first pig-to-human transplant on a living patient. He died two months after the milestone, with the presence of porcine cytomegalovirus in the organ later blamed for his death.
Headline
South Korea, Japan Protest China, Russia Aircraft Incursions
South Korea and Japan reacted furiously on Wednesday after Chinese and Russian military aircraft conducted joint patrols around the two countries, with both Seoul and Tokyo scrambling jets.
South Korea said it had protested with representatives of China and Russia, while Japan said it had conveyed its “serious concerns” over national security.
According to Tokyo, two Russian Tu-95 nuclear-capable bombers on Tuesday flew from the Sea of Japan to rendezvous with two Chinese H-6 bombers in the East China Sea, then conducted a joint flight around the country.
The incident comes as Japan is locked in a dispute with China over comments Prime Minister Sanae Takaichi made about Taiwan.
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The bombers’ joint flights were “clearly intended as a show of force against our nation, Defence Minister Shinjiro Koizumi wrote on X Wednesday.
Top government spokesman Minoru Kihara said that Tokyo had “conveyed to both China and Russia our serious concerns over our national security through diplomatic channels”.
Seoul said Tuesday the Russian and Chinese warplanes entered its air defence zone and that a complaint had been lodged with the defence attaches of both countries in the South Korean capital.
“Our military will continue to respond actively to the activities of neighbouring countries’ aircraft within the KADIZ in compliance with international law,” said Lee Kwang-suk, director general of the International Policy Bureau at Seoul’s defence ministry, referring to the Korea Air Defence Identification Zone.
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South Korea also said it deployed “fighter jets to take tactical measures in preparation for any contingencies” in response to the Chinese and Russian incursion into the KADIZ.
The planes were spotted before they entered the air defence identification zone, defined as a broader area in which countries police aircraft for security reasons but which does not constitute their airspace.
Japan’s defence ministry also scrambled fighter jets to intercept the warplanes.
Beijing later Tuesday confirmed it had organised drills with Russia’s military according to “annual cooperation plans”.
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Moscow also described it as a routine exercise, saying it lasted eight hours and that some foreign fighter jets followed the Russian and Chinese aircraft.
Since 2019, China and Russia have regularly flown military aircraft into South Korea’s air defence zone without prior notice, citing joint exercises.
In November last year, Seoul scrambled jets as five Chinese and six Russian military planes flew through its air defence zone.
Similar incidents occurred in June and December 2023, and in May and November 2022.
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Meanwhile, Tokyo said Monday it had scrambled jets in response to repeated takeoff and landing exercises involving fighter jets and military helicopters from China’s Liaoning aircraft carrier as it cruised in international waters near Japan.
It also summoned Beijing’s ambassador after military aircraft from the Liaoning locked radar onto Japanese jets, the latest incident in the row ignited by Takaichi’s comments backing Taiwan.
Takaichi suggested last month that Japan would intervene militarily in any Chinese attack on the self-ruled island, which Beijing claims as its own and has not ruled out seizing by force.
AFP
Headline
Thousands Reported To Have Fled DR Congo Fighting As M23 Closes On Key City
Fierce fighting rocked the eastern Democratic Republic of Congo on Tuesday as the Rwanda-backed M23 militia rapidly advanced towards the strategic city of Uvira, with tens of thousands of people fleeing over the nearby border into Burundi, sources said.
The armed group and its Rwandan allies were just a few kilometres (miles) north of Uvira, security and military sources told AFP.
The renewed violence undermined a peace agreement brokered by US President Donald Trump that Kinshasa and Kigali signed less than a week ago, on December 4.
Trump had boasted that the Rwanda-DRC conflict was one of eight he has ended since returning to power in America in January.
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With the new fighting, more than 30,000 people have fled the area around Uvira for Burundi in the space of a week, a UN source and a Burundian administrative source told AFP.
The Burundian source told AFP on condition of anonymity he had recorded more than 8,000 daily arrivals over the past two days, and 30,000 arrivals in one week. A source in the UN refugee agency confirmed the figure.
The Rwanda-backed M23 offensive comes nearly a year after the group seized control of Goma and Bukavu, the two largest cities in eastern DRC, a strategic region rich in natural resources and plagued by conflict for 30 years.
Local people described a state of growing panic as bombardments struck the hills above Uvira, a city of several hundred thousand residents.
“Three bombs have just exploded in the hills. It’s every man for himself,” said one resident reached by telephone.
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“We are all under the beds in Uvira — that’s the reality,” another resident said, while a representative of civil society who would not give their name described fighting on the city’s outskirts.
Fighting was also reported in Runingo, another small locality some 20 kilometres (12 miles) from Uvira, as the M23 and the Rwandan army closed in.
Burundi views the prospect of Uvira falling to Rwanda-backed forces as an existential threat, given that it sits across Lake Tanganyika from Burundi’s economic capital Bujumbura.
The city is the main sizeable locality in the area yet to fall to the M23 and its capture would essentially cut off the zone from DRC control.
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Burundi deployed about 10,000 soldiers to eastern DRC in October 2023 as part of a military cooperation agreement, and security sources say reinforcements have since taken that presence to around 18,000 men.
The M23 and Rwandan forces launched their Uvira offensive on December 1.
Rich in natural resources, eastern DRC has been choked by successive conflicts for around three decades.
Violence in the region intensified early this year when M23 fighters seized the key eastern city of Goma in January, followed by Bukavu, capital of South Kivu province, a few weeks later.
– Regional risk –
The peace deal meant to quell the fighting was signed last Thursday in Washington by Congolese President Felix Tshisekedi and his Rwandan counterpart Paul Kagame, with Trump — who called it a “miracle” deal — also putting his signature to it.
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The agreement includes an economic component intended to secure US supplies of critical minerals present in the region, as America seeks to challenge China’s dominance in the sector.
But even on the day of the signing, intense fighting took place in South Kivu, where Uvira is located, which included the bombing of houses and schools.
Witnesses and military sources in Uvira said that Congolese soldiers fleeing the fighting had arrived in the city overnight Monday and shops were looted at dawn.
Several hundred Congolese and Burundian soldiers had already fled to Burundi on Monday, according to military sources, since the M23 fighters embarked on their latest offensive from Kamanyola, some 70 kilometres north of Uvira.
Since the M23’s lightning offensive early this year, the front had largely stabilised over the past nine months.
Burundian President Evariste Ndayishimiye warned in February there was a danger of the conflict escalating into a broader regional war, a fear echoed by the United Nations.
Headline
‘Santa Claus’ Arrested For Possessing, Distributing Child Sexual Abuse Material
A 64-year-old man from Hamilton Township has been arrested in the United States after investigators linked him to the possession and distribution of child sexual abuse material.
The suspect, identified as Mark Paulino, had been working as a “Santa for hire” at holiday events, a role that placed him in repeated contact with children.
Mercer County officials said the investigation began on 4 December when detectives were alerted to suspicious online activity involving the uploading of child pornography from a residence in Hamilton Township. The probe quickly identified Paulino, a retired elementary school teacher, as the person involved.
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Police stated that Paulino had presented himself online as a retired teacher and had recently performed as Santa Claus for photographs and private, corporate, and organisational events. “Because this role involved direct, repeated contact with children, detectives worked around the clock to secure a search warrant,” authorities explained.
The warrant was executed on 5 December, during which police seized multiple items regarded as evidentiary. Paulino was taken into custody without incident and charged with possession and distribution of child sexual abuse materials, as well as endangering the welfare of a child.
Prosecutors have filed a motion to detain him pending trial. The investigation remains ongoing, and authorities have urged members of the public with relevant information to come forward.
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