Headline

Pig Kidney Functioning In Human For More Than A Month

Published

2 years ago

August 16, 2023

Editor

A genetically-modified pig kidney is continuing to function well a record-breaking 32 days after it was transplanted into a brain dead patient, a medical center said Wednesday.

The experimental procedure is part of a growing field of research aimed at advancing cross-species organ donation and thus reducing transplant waiting lists.

There are more than 103,000 people waiting for transplants in the United States, 88,000 of whom need kidneys.

“This work demonstrates a pig kidney -— with only one genetic modification and without experimental medications or devices — can replace the function of a human kidney for at least 32 days without being rejected,” said surgeon Robert Montgomery, director of the NYU Langone Transplant Institute.

Montgomery carried out the first genetically modified pig kidney transplant to a human in September 2021, followed by a similar procedure in November 2021. There have since been a handful of other cases.

While previous such transplants have involved up to 10 modifications, the latest experiment involved just one: the gene involved in the so-called “hyperacute rejection,” which would otherwise occur within minutes of an animal organ being connected to a human circulatory system.

By “knocking out” the gene responsible for a biomolecule called alpha-gal — which otherwise would be a prime target for human antibodies — the NYU Langone team were able to stop immediate rejection.

“We’ve now gathered more evidence to show that, at least in kidneys, just eliminating the gene that triggers a hyperacute rejection may be enough along with clinically approved immunosuppressive drugs to successfully manage the transplant in a human for optimal performance—potentially in the long-term,” said Montgomery.

They also embedded the pig’s thymus gland — responsible for educating the immune system — in the kidney’s outer layer, in order to prevent a more delayed host rejection.

Both of the patient’s own kidneys were removed, then one pig kidney was transplanted, and started immediately producing urine.

Monitoring showed that levels of creatinine, a waste product, were at optimal levels, and there was no evidence of rejection.

Crucially, no evidence of porcine cytomegalovirus — which may trigger organ failure — have been detected, and the team plan to continue monitoring for another month.

The research was made possible by the family of the 57-year-old male patient who had elected to make his body available for science.

In January 2022, surgeons at the University of Maryland Medical School carried out the world’s first pig-to-human transplant on a living patient. He died two months after the milestone, with the presence of porcine cytomegalovirus in the organ later blamed for his death.

Headline

42 Killed In Israeli Attacks, Says Gaza’s Civil Defense

Published

5 hours ago

August 24, 2025

Editor

Gaza’s civil defence agency reported at least 42 people killed in Israeli attacks on Sunday, as the Israeli army prepared for a new assault on the Palestinian territory’s largest city.

Civil defence spokesman Mahmud Bassal said there had been several air strikes around Gaza City — which the military is gearing up to capture — including one in the Al-Sabra neighbourhood that killed eight people.

Attacks were also reported elsewhere across the territory, he said, with the “total tally currently rising to 42 dead”.

The army did not immediately respond to a request for comment on the figure.

“The situation is extremely dangerous… Each day, each minute, there are bombings, martyrs, death and blood — we can’t take it anymore,” Al-Sabra resident Ibrahim Al-Shurafa told AFP, explaining strikes and shelling were ongoing.

“We don’t know where to go. Death follows us everywhere,” he added.

Media restrictions in Gaza and difficulties in accessing many areas mean AFP is unable to independently verify the tolls and details provided by the civil defence agency or the Israeli military.

The October 2023 Hamas attack on Israel that sparked the war resulted in the deaths of 1,219 people, mostly civilians, according to an AFP tally based on official figures.

Israel’s offensive has killed at least 62,686 Palestinians, most of them civilians, according to figures from the health ministry in Hamas-run Gaza that the United Nations considers reliable.

AFP

Headline

Venezuela Frees Eight Opposition Leaders

Published

5 hours ago

August 24, 2025

Editor

Venezuelan authorities released eight opposition leaders from jail early Sunday, including a former congressman and two Italian citizens, and granted house arrest to five others, an opposition politician said.

Most of those released had been charged with corruption in opposition-run mayoral offices.

Also set free was Congressman, Amirico de Grazia, detained amid protests that erupted during President Nicolas Maduro’s reelection in 2024.

“Today, several families are once again embracing their loved ones. We know there are many left, and we have not forgotten them; we continue to fight for everyone,” two-time former presidential candidate Henrique Capriles said on X.

Opposition leaders Victor Jurado, Simon Vargas, Arelis Ojeda Escalante, Mayra Castro, Diana Berrio, Gorka Carnevalli, as well as Italian nationals Margarita Assenzo and de Grazia were released, Capriles said.

Nabil Maalouf, Valentin Gutierrez Pineda, Rafael Ramirez, Pedro Guanipa, and David Barroso were placed under house arrest.

The Italian government confirmed the release of de Grazia and Assenzo, who must appear in court to clarify the conditions of their release. It also vowed to continue working on securing the release of other detained Italians.

“We have always said, and we maintain it: we will talk to whomever we need to talk to so that there is not a single political prisoner in our Venezuela!” Capriles added.

AFP

Headline

Russia, Ukraine Exchange Prisoners Of War, Civilians

Published

5 hours ago

August 24, 2025

Editor

Russia and Ukraine each sent back more prisoners of war on Sunday in the latest in a series of exchanges that have seen hundreds of POWs released this year, the two sides said.

Large-scale prisoner exchanges were the only tangible result of three rounds of talks between Russia and Ukraine in Istanbul between May and July.

They remain one of the few areas of cooperation between the two countries since Russia’s offensive began in 2022.

“On August 24, 146 Russian servicemen were returned from the territory controlled” by Kyiv, the Russian defence ministry said on Telegram.

“In exchange, 146 prisoners of war of the Ukrainian Armed Forces were transferred” to Ukraine, it added. Ukraine did not confirm any figures for the release.

Russia also said that “eight citizens of the Russian Federation—residents of the Kursk region, illegally detained” by Kyiv were also returned.

Ukrainian forces launched a surprise incursion into Russia’s Kursk region in August last year, seizing hundreds of square kilometres (miles) of territory in a major setback for the Kremlin.

Russia deployed thousands of troops from its ally North Korea as part of a counterattack but did not fully reclaim the region until April.

Among the Ukrainians released on Sunday was journalist Dmytro Khyliuk, President Volodymyr Zelensky said.

Khyliuk was kidnapped in the Kyiv region in March 2022. He is finally home in Ukraine,” Zelensky said on social media.

Also freed was former Kherson mayor Volodymyr Mykolayenko, “who spent more than three years in captivity,” Zelensky’s aide Andriy Yermak wrote on X.

“In 2022, he was on the list for return, but Volodymyr voluntarily refused to be exchanged in favour of a seriously ill prisoner with whom he was sharing a cell in a Russian prison,” Yermak said.

AFP