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The End Of Infertility? Skin Cells Used To Create Fertilizable Human Eggs

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Scientists said Tuesday they have turned human skin cells into eggs and fertilised them with sperm in the lab for the first time — a breakthrough that is hoped to one day let infertile people have children.

The technology is still years away from potentially becoming available to aspiring parents, the US-led team of scientists warned.

But outside experts said the proof-of-concept research could eventually change the meaning of infertility, which affects one in six people worldwide.

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If successful, the technology called in-vitro gametogenesis (IVG) would allow older women or women who lack eggs for other reasons to genetically reproduce, Paula Amato, the co-author of a new study announcing the achievement, told AFP.

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It also would allow same-sex couples to have a child genetically related to both partners,” said Amato, a researcher at the Oregon Health & Science University in the United States.

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Scientists have been making significant advances in this field in recent years, with Japanese researchers announcing in July they had created mice with two biological fathers.

But the new study, published in the journal Nature Communications, marks a major advance by using DNA from humans, rather than mice.

The scientists first removed the nucleus from normal skin cells and transferred them into a donor egg which had its nucleus removed. This technique, called somatic cell nuclear transfer, was used to clone Dolly the sheep in 1996.

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However a problem still had to be overcome: skin cells have 46 chromosomes, but eggs have 23.

The scientists managed to remove these extra chromosomes using a process they are calling “mitomeiosis”, which mimics how cells normally divide.

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They created 82 developing eggs called oocytes, which were then fertilised by sperm via in vitro fertilisation (IVF).

After six days, less than nine percent of the embryos developed to the point that they could hypothetically be transferred to the uterus for a standard IVF process.

READ ALSO:Why Nigeria Needs University Of Mining And Geosciences – Senator

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However the embryos displayed a range of abnormalities, and the experiment was ended.

While the nine-percent rate was low, the researchers noted that during natural reproduction only around a third of embryos make it to the IVF-ready “blastocyst” stage.

Amato estimated the technology was at least a decade away from becoming widely available.

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The biggest hurdle is trying to achieve genetically normal eggs with the correct number and complement of chromosomes,” she said.

READ ALSO:Senate Approves Establishment Of Medical Sciences Varsity In Six Geopolitical Zones

Breakthrough

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Ying Cheong, a reproductive medicine researcher at the UK’s University of Southampton, hailed the “exciting” breakthrough.

“For the first time, scientists have shown that DNA from ordinary body cells can be placed into an egg, activated, and made to halve its chromosomes, mimicking the special steps that normally create eggs and sperm,” she said.

“While this is still very early laboratory work, in the future it could transform how we understand infertility and miscarriage, and perhaps one day open the door to creating egg- or sperm-like cells for those who have no other options.”

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Other researchers trying to create eggs in the lab are using a different technique. It involves reprogramming skin cells into what are called induced pluripotent stem cells — which have the potential to develop into any cell in the body — then turning those into eggs.

It’s too early to tell which method will be more successful,” Amato said. “Either way, we are still many years away.”
The researchers followed existing US ethical guidelines regulating the use of embryos, the study said.
(GUARDIAN)

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Trump’s Airstrikes: Halt Military Cooperation With US Immediately – Sheikh Gumi Tells Tinubu Govt

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Islamic cleric, Sheikh Ahmad Gumi has called on the Federal Government to immediately halt all military cooperation with the United States following reported US airstrikes.

Gumi warned that American involvement could worsen Nigeria’s security challenges and undermine national sovereignty.

Gumi made the call in a statement posted on his Facebook page on Friday.

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He said while Islam permits the fight against terrorism, such actions should only be carried out by what he described as “clean hands,” arguing that the United States lacks the moral authority to lead such efforts because of its global military record.

READ ALSO:US Dept Of War Shares Video Of Air Strikes In Nigeria

According to the cleric, Nigeria made a mistake by allowing foreign powers to play a role in its counterterrorism operations, insisting that “terrorists do not truly fight terrorists” and that such interventions often result in civilian casualties and hidden political motives.

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Gumi warned that allowing Nigeria to become a theatre of war would attract anti-US forces into the country, further destabilising it.

He also cautioned that US involvement, particularly under claims of protecting Christians, could polarise the country along religious lines.

READ ALSO:Trump To Attend FIFA World Cup Finals Draw On Friday

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The cleric further argued that airstrikes alone cannot defeat terrorism, stressing that effective counterterrorism requires strong ground operations, which he said Nigeria has enough personnel to carry out if properly organised.

This is the mistake Nigeria has made. Terrorists don’t fight terrorists in truth; they may only kill innocent people and have ulterior motives behind the drama of fighting ‘terror’.

“As a principle, no nation should allow its land to be a theater of war. And no nation should allow its neighbors to be their enemies.

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“If Nigeria wants military assistance, China, Turkey, and Pakistan can do the job effectively,” part of his statement reads.

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Shehu Sani Reacts To Trump’s Military Strikes In Nigeria

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Former lawmaker, senator Shehu Sani, has reacted to reports of United States military strikes on terrorist targets in Nigeria’s North-West, saying foreign powers cannot permanently handle the country’s security challenges.

Sani made the remarks on Friday via his X handle while responding to a post by the United States Africa Command, AFRICOM, which indicated that the strikes were carried out in coordination with Nigerian authorities.

According to him, if the reported strikes were indeed a joint operation with Nigerian security agencies, then such action was justifiable, given the threat posed by terrorist groups in the region.

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READ ALSO:US Dept Of War Shares Video Of Air Strikes In Nigeria

He described terrorists operating in parts of northern Nigeria as “cancerous cells,” stressing that they survive through violence and should be confronted decisively.

Sani also dismissed narratives suggesting that terrorist attacks target only one religious group, describing such claims as false and misleading.

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He said: “If actually, the military strikes against the terrorists targets in the North Western part of Nigeria were a joint operation with the ‘Nigerian Authorities’ as posted by the US AFRICOM on their verified X handle, then it’s a conscionable action.

READ ALSO:JUST IN: US Forces Bomb Terrorists Camps In Nigeria

“Terrorists have become cancerous cells in our part of the country.They live by the sword.The narrative that the evil terrorists only targets one faith, remains absolutely false and misleading.

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“Again, the ultimate security and peace in our country lies with ourselves and not with the US or any foreign power. They can complimentarily or unilaterally strike, but they can’t eternally fight our battles.”

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UKWU! Timaya Falls On Stage While Trying To Lift Plus-sized Woman During Performance [VIDEO]

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Nigerian singer, Timaya fell on stage while trying to lift a plus-sized lady during performance.

The incident occurred during his ‘Ukwu’ performance at the Gbaramatu Christmas Carnival in Delta State.

READ ALSO:Saboteurs Against Presidential Amnesty Reforms – General Ndiomu

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Timaya in a now trending video on social media collapsed after the plus-sized woman jumped on him midday into his performance.

The singer later got up and continued his performance amid cheers from the crowd.

Watch video here

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https://x.com/hypetribeng/status/2004263337572684157?s=20

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