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US Surgeons Report Longest Successful Pig-to-human Kidney Transplant

Published

2 years ago

September 15, 2023

Editor

The United States surgeons have announced that they concluded their experiment after a groundbreaking 61 days, where they transplanted a genetically modified pig kidney into a brain-dead patient, marking a significant milestone in the field of organ transplantation.

This new experimental procedure is part of a rapidly developing area of study focused on advancing cross-species transplants. The technique is primarily being tested on donated bodies for scientific purposes.

In the United States, there are over 103,000 individuals on the organ transplant waiting list, with 88,000 of them specifically in need of kidneys.

“We have learned a great deal throughout these past two months of close observation and analysis, and there is great reason to be hopeful for the future,” said Robert Montgomery, director of the New York University Langone Transplant Institute, who led the surgery in July.

This was the fifth xenotransplant performed by Montgomery, who previously conducted the world’s first genetically modified pig kidney transplant in September 2021.

Tissue collected during the study showed signs of a mild rejection process, which led to a need for increased immunosuppression medication.

By “knocking out” the gene responsible for a biomolecule called alpha-gal — a prime target for roving human antibodies — the NYU Langone team was able to stop immediate rejection.

The donor pig in this experiment came from a herd cultivated by Virginia-based biotech company Revivicor.

The Food and Drug Administration has granted approval for the herd to serve as a meat source for individuals with alpha-gal molecule hypersensitivity, which is caused by certain tick bites. These pigs are bred rather than cloned, making the process more scalable.

In the past, early xenotransplantation research centered around using organs from primates. For instance, in 1984, a baboon’s heart was transplanted into a newborn called “Baby Fae,” but unfortunately, she only survived for 20 days.

Nowadays, the focus has shifted to pigs as potential donors for humans. Pigs are considered suitable due to their organ size, rapid growth, large litters, and the fact that they are already raised for food.

In January 2022, surgeons at the University of Maryland Medical School achieved a groundbreaking accomplishment by performing the first-ever pig-to-human heart transplant on a living patient.

Unfortunately, the patient passed away two months after the procedure, and it was later determined that the presence of porcine cytomegalovirus in the organ was to blame.

Chinese scientists recently published a paper demonstrating their achievement of creating hybrid pig-human kidneys in pig embryos. This alternative approach has the potential to address organ donation shortages in the future.

However, the development has raised ethical concerns, particularly because human cells were discovered in the pigs’ brains, according to experts.

Headline

Afghanistan-Pakistan Border Clashes Escalate After Alleged Air Strikes

Published

1 day ago

October 11, 2025

Editor

Afghanistan’s Taliban forces launched armed reprisals against Pakistani soldiers along the shared border on Saturday, accusing Islamabad of carrying out air strikes on its soil, senior officials from several provinces said Saturday.

On Thursday, two explosions were heard in the Afghan capital and another in the southeast of the country. The following day, the Taliban-run defence ministry blamed the attacks on Pakistan, accusing its neighbor of violating its sovereignty.

“In retaliation for air strikes carried out by the Pakistani army on Kabul,” Taliban forces are engaged “in heavy clashes against Pakistani security forces in various areas” along the border, the Afghan military said in a statement.

Islamabad did not confirm that it was behind Thursday’s attacks, but called on Kabul “to stop harbouring the Pakistani Taliban (TTP) on its soil.”

The TTP, trained in combat in Afghanistan and claiming to share the same ideology as the Afghan Taliban, is accused by Islamabad of having killed hundreds of its soldiers since 2021.

Taliban officials from Kunar, Nangarhar, Paktia, Khost, and Helmand provinces — all located on the border between Pakistan and Afghanistan — confirmed that clashes were ongoing.

“This evening, Taliban forces began using weapons. We fired first light and then heavy artillery at four points along the border,” a senior official in Pakistan’s Khyber-Pakhtunkhwa province, bordering Afghanistan, told AFP.

“Pakistani forces responded with heavy fire and shot down three Afghan quadcopters suspected of carrying explosives. Intense fighting continues, but so far, no casualties have been reported,” he continued.

– Uptick in violence –

In recent months, TTP militants have intensified their campaign of violence against Pakistani security forces in the mountainous areas bordering Afghanistan.

Islamabad accuses Afghanistan of failing to expel militants who use Afghan territory to launch attacks on Pakistan, an accusation denied by authorities in Kabul.

The TTP and its affiliates are behind most of the violence — largely directed at security forces.

Earlier this year, a UN report said the TTP “receive substantial logistical and operational support from the de facto authorities”, referring to the Taliban government in Kabul.

Pakistani Defence Minister Khawaja Muhammad Asif told parliament on Thursday that several efforts to convince the Afghan Taliban to stop backing the TTP had failed.

“We will not tolerate this any longer,” Asif said. “United, we must respond to those facilitating them, whether the hideouts are on our soil or Afghan soil.”

Earlier Saturday, the TTP claimed responsibility for deadly attacks in several districts in northwest Pakistan that killed 20 security officials and three civilians.

AFP

Headline

Taliban Attacks Kill 23 In Northwestern Pakistan

Published

1 day ago

October 11, 2025

Editor

The Pakistani Taliban on Saturday claimed responsibility for deadly attacks in several northwestern districts that killed 20 security officials and three civilians.

The attacks, which included a suicide bombing on a police training school, were carried out on Friday in several districts of Khyber Pakhtunkhwa province that borders Afghanistan.

Militancy has surged in Khyber Pakhtunkhwa since the withdrawal of US-led troops from neighbouring Afghanistan in 2021 and the return of the Taliban government in Kabul.

Eleven paramilitary troops were killed in the border Khyber district, while seven policemen were killed after a suicide bomber rammed an explosives-laden car into the gate of a police training school, which was followed by a gun attack.

Five people, including three civilians, were killed in a separate clash in Bajaur district, security officials told AFP on Saturday.

The Pakistani Taliban, the Tehreek-e-Taliban (TTP), claimed responsibility for the attacks in messages on social media. The group is separate from but closely linked with the Afghan Taliban.

The attacks came hours after Afghanistan’s Taliban government accused Pakistan of “violating Kabul’s sovereign territory”, a day after two explosions were heard in the capital.

Pakistan did not say if it was behind the blasts in Kabul, but said it had the right to defend itself against surging border militancy.

Islamabad accuses Afghanistan of failing to expel militants using Afghan territory to launch attacks on Pakistan, an accusation that authorities in Kabul deny.

The TTP and its affiliates are behind most of the violence — largely directed at security forces.

Including Friday’s attacks, at least 32 Pakistani troops and three civilians have been killed this week alone in the border regions.

AFP

Headline

US Threatens To Sanction Countries That Vote For Shipping Carbon Tax

Published

1 day ago

October 11, 2025

Editor

The United States on Friday threatened to impose sanctions and take other punitive action against any country that votes in favor of a carbon tax on maritime transportation to be implemented through a UN agency.

“We will fight hard to protect our economic interests by imposing costs on countries if they support” the Net Zero Framework, said a joint statement by US Secretary of State Marco Rubio and his counterparts at the departments of energy and transportation.

Members of the London-based International Maritime Organization (IMO) are set to vote next week on the adoption of the Net Zero Framework (NZF) agreement aimed at reducing global carbon emissions from the shipping sector.

Washington, however, described the proposal as imposing “a global carbon tax on the world.”

Since returning to power in January, US President Donald Trump has reversed Washington’s course on climate change, denouncing it as a “scam” and encouraging fossil fuel use by deregulation.

In the statement, Rubio, Energy Secretary Chris Wright and Transportation Secretary Sean Duffy said the Trump administration “unequivocally rejects” the NZF proposal.

They threatened a range of punishing actions against countries that vote in favor of the framework, including: visa restrictions; blocking vessels registered in those countries from US ports; imposing commercial penalties; and considering sanctions on officials.

“The United States will be moving to levy these remedies against nations that sponsor this European-led neocolonial export of global climate regulations,” the statement said.