Health

Why Some People Don’t Get Sick From COVID-19 Infection — Study

Published

2 years ago

July 22, 2023

The so-called “super dodgers,” who get COVID-19 but show no symptoms, may have a hereditary advantage. According to a recent study done by researchers from the University of California, San Francisco, they are more than twice as likely to have a particular gene variation that aids them in killing the virus.

The study, which was released on July 19, 2023 in Nature, provides the first concrete proof that asymptomatic SARS-CoV-2 has a genetic foundation. The study contributes to unraveling the riddle of why some people can contract COVID-19 infection without ever becoming ill. The discovery points to new targets for drugs and vaccines.

“If you have an army that’s able to recognize the enemy early, that’s a huge advantage,” explained the study’s lead researcher, Jill Hollenbach, a professor of neurology, as well as epidemiology and biostatistics, and a member of the Weill Institute for Neurosciences at UCSF.

”It’s like having soldiers that are prepared for battle and already know what to look for, and that these are the bad guys.”

The mutation — HLA-B15:01 — is quite common, carried by about 10 percent of the study’s population. It doesn’t prevent the virus from infecting cells but, rather, prevents people from developing any symptoms. That includes a runny nose or even a barely noticeable sore throat./ UCSF researchers found that 20 percent of people in the study who remained asymptomatic after infection carried at least one copy of the HLA-B15:01 variant, compared to 9 percent of those who reported symptoms. Those who carried two copies of the variant were far more likely — more than eight times — to avoid feeling sick.

“We did not set out to study genetics, but we were thrilled to see this result come from our multidisciplinary collaboration with Dr. Hollenbach and the National Marrow Donor Programme,” said Mark Pletcher, a professor of epidemiology and biostatistics at UCSF.

The primary study group was limited to those who self-identified as white because the final set of study respondents did not have enough people in it from other ethnic and racial groups to analyze.

Researchers identified 1,428 unvaccinated donors who tested positive between February 2020 and the end of April 2021, before the vaccines were widely available and when it still took many days to get back test results.

Of these, 136 individuals remained asymptomatic for at least two weeks before and after testing positive. Only one of the HLA variants — HLA-B*15:01 — had a strong association with asymptomatic COVID-19 infection, and this was reproduced in two independent cohorts.

“Risk factors for severe COVID-19, like being older, overweight and having chronic diseases like diabetes did not appear to play a role in who remained asymptomatic.

“We are proud to partner on research that has the potential to leverage a long-term public investment in building the national registry to help cure diseases and improve our ability to avoid future pandemics,” said Martin Maiers, vice president of research at the National Marrow Donor Programme/Be The Match.

VANGUARD

Health

LASG FLags Off Polio Outbreak Response Campaign

Published

5 months ago

January 20, 2025

Editor

The Lagos State Government, through the Lagos State Primary Health Care Board, has launched the 2025 Polio Outbreak Response Campaign, reaffirming its commitment to eradicating polio and safeguarding the health of its children.

The ceremony, held at the Simpson Primary Healthcare Centre, was led by the First Lady of Lagos State, Dr. (Mrs.) Claudiana Ibijoke Sanwo-Olu, represented by Mrs. Widad Jumoke Mustafa, a member of the Committee of Wives of Lagos State Officials (COWLSO).

In her address, the First Lady emphasised the state government’s proactive measures to keep Lagos polio-free, highlighting the critical importance of the campaign in preventing the debilitating effects of poliomyelitis, which can result in paralysis or death.

The First Lady also called on parents, community leaders, and stakeholders to support the campaign by ensuring eligible children are vaccinated.

Targeting children aged 0-59 months, vaccination teams will administer the Oral Polio Vaccine (OPV) to prevent virus transmission.

Dr. Kemi Ogunyemi, the Special Adviser on Health, expressed gratitude to Lagosians for their continued cooperation in the fight against polio. While appreciating all healthcare workers and partners for their services, Mrs. Ogunyemi encouraged parents to present their children and wards for the exercise.

Also speaking, the Chairman of Lagos Mainland Local Government, Mrs. Omolola Rashidat Essien opined that Immunization is key in ensuring that children are kept safe from polio and other vaccine preventable diseases.

Dr. Abimbola Bowale, the Supervising Permanent Secretary, Lagos State Primary Health Care Board, who also spoke at the event, underscored the life-saving importance of immunization.

“All children aged 0-59 months need multiple doses of the polio vaccine to ensure full protection. Any child missed represents a potential risk for the poliovirus to spread. The vaccine is safe, effective, and crucial in keeping our communities polio-free,” he stated.

Dr. Bowale also outlined several strategies to ensure the success of the campaign, including fixed post teams stationed at primary healthcare centres and public health facilities, house-to-house visits, and a transit strategy to reach special locations such as places of worship, schools, motor parks, and other public venues.

The event concluded with Dr. (Mrs.) Claudiana Ibijoke Sanwo-Olu officially launched the campaign, marking a renewed effort to maintain Lagos State’s polio-free status.

Headline

Lagos Cholera Cases Rise To 421

Published

12 months ago

June 22, 2024

Editor

The Lagos state suspected cholera cases have risen to 421.

The Commissioner for Health, Akin Abayomi disclosed this on his Instagram handle @profakinabayomi on Saturday.

“As of June 20, 2024, an additional four suspected cholera cases have been reported, as illustrated in the accompanying graph,” he wrote.

He noted that the Emergency Operations Centre in collaboration with all relevant partners is actively engaged in contact tracing, community-based surveillance, awareness campaigns, sample testing, and ensuring that confirmed cholera cases receive appropriate medical treatment.

On Friday, the commissioner confirmed 35 cases out of the 417 suspected cases and 24 deaths across 20 Local Government Areas in the state.

The cases were reported from Agege, Badagry, Ikeja, Mushin, Ajeromi-Ifelofun, Epe, Ikorodu, Ojo, Alimosho, and Eti-Osa.

Others were Kosofe, Oshodi-Isolo, Amuwo-Odofin, Ibeju-Lekki, Lagos Island, Shomolu, Apapa, Ifako-Ijaiye, Lagos mainland, and Surulere.

Cholera is a food and water-borne disease caused by ingesting the bacteria— Vibrio cholerae — in contaminated water and food. Cholera can cause severe acute watery diarrhoea, and the severe forms of the disease can kill within hours if left untreated.

In Nigeria, cholera is an endemic and seasonal disease, occurring annually mostly during the rainy season and more frequently in areas with poor sanitation.

The World Health Organisation on Thursday announced a spike in cholera in several regions of the world, with almost 195,000 cases and over 1,900 deaths reported in 24 countries since the start of 2024.

WHO said the Eastern Mediterranean Region reported the highest number of cases, followed by the African Region, the Region of the Americas, the Southeast Asia Region, and the European Region.

The global health body, however, noted that there are no reported cases in the Western Region, according to its bulletin released on Wednesday.

It said it exhausted its global stockpile of Oral Cholera Vaccines by March but was able to exceed “the emergency target of five million doses in early June for the first time in 2024.”

Health

AUTISM: What You Need To Know

Published

1 year ago

April 6, 2024

Editor

By Silver Yeibake

Autism, commonly known as Autism Spectrum Disorder (ASD), is a neurodevelopmental disorder that affects communication, social interaction, and behavior. Autism is referred to as a spectrum condition since it can manifest in a variety of symptoms and abilities. While the actual cause of autism is unknown, evidence suggests that genetic and environmental factors interact to influence its development.

The risk factors include a sibling with autism, advanced age of parents, exposure to certain air pollutants and pesticides before birth, extreme prematurity, mothers with diabetes, immune system disorders or obesity, any difficulty with delivery leading to deprivation of oxygen to the baby’s brain, fever during pregnancy, lack of certain vitamins minerals during pregnancy, and certain genetic conditions, such as Down, fragile X, and Rett syndromes.

“Risk factors can not on their own cause a disease. However, they can increase the likelihood of that disease in a person.”

It is important to know that contrary to trending claims online, there is no scientific or medical evidence that vaccines or consumption of sugar are risk factors for autism.

Autism is defined by difficulties in social interaction and communication. Individuals with autism may struggle to grasp social cues, maintain eye contact, and engage in typical back-and-forth conversations. Some people may also engage in meaningless, repetitive actions, such as hand-flapping or rocking, and have strong interests in specific areas.

It is essential to remember that autism is a lifelong diagnosis, but with early intervention and adequate care, people with autism can live fulfilling lives.
Autism treatment frequently includes behavioral therapy, speech therapy, occupational therapy, and social skills training. Each individual with autism is unique, thus interventions should be tailored to meet their personal needs and strengths.

In spite of the difficulties that autism can cause, many people with autism possess unique talents and abilities. Some people may succeed in fields such as music, art, mathematics, or programming, thus it is important for society to acknowledge and honor the qualities and achievements of people with autism.

In summary, autism is a complicated and diverse disorder that affects individuals in various ways. By raising autism knowledge, understanding, and acceptance, we can build a more inclusive society in which people with autism can thrive and attain their full potential.

Dr. Yeibake, Weriwoyingipre Silver.
Senior Registrar,
Faculty Of Pediatrics,
WACP