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Why Some People Don’t Get Sick From COVID-19 Infection — Study

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The so-called “super dodgers,” who get COVID-19 but show no symptoms, may have a hereditary advantage. According to a recent study done by researchers from the University of California, San Francisco, they are more than twice as likely to have a particular gene variation that aids them in killing the virus.

The study, which was released on July 19, 2023 in Nature, provides the first concrete proof that asymptomatic SARS-CoV-2 has a genetic foundation. The study contributes to unraveling the riddle of why some people can contract COVID-19 infection without ever becoming ill. The discovery points to new targets for drugs and vaccines.

“If you have an army that’s able to recognize the enemy early, that’s a huge advantage,” explained the study’s lead researcher, Jill Hollenbach, a professor of neurology, as well as epidemiology and biostatistics, and a member of the Weill Institute for Neurosciences at UCSF.

”It’s like having soldiers that are prepared for battle and already know what to look for, and that these are the bad guys.”

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The mutation — HLA-B15:01 — is quite common, carried by about 10 percent of the study’s population. It doesn’t prevent the virus from infecting cells but, rather, prevents people from developing any symptoms. That includes a runny nose or even a barely noticeable sore throat./ UCSF researchers found that 20 percent of people in the study who remained asymptomatic after infection carried at least one copy of the HLA-B15:01 variant, compared to 9 percent of those who reported symptoms. Those who carried two copies of the variant were far more likely — more than eight times — to avoid feeling sick.

“We did not set out to study genetics, but we were thrilled to see this result come from our multidisciplinary collaboration with Dr. Hollenbach and the National Marrow Donor Programme,” said Mark Pletcher, a professor of epidemiology and biostatistics at UCSF.

The primary study group was limited to those who self-identified as white because the final set of study respondents did not have enough people in it from other ethnic and racial groups to analyze.

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Researchers identified 1,428 unvaccinated donors who tested positive between February 2020 and the end of April 2021, before the vaccines were widely available and when it still took many days to get back test results.

Of these, 136 individuals remained asymptomatic for at least two weeks before and after testing positive. Only one of the HLA variants — HLA-B*15:01 — had a strong association with asymptomatic COVID-19 infection, and this was reproduced in two independent cohorts.

“Risk factors for severe COVID-19, like being older, overweight and having chronic diseases like diabetes did not appear to play a role in who remained asymptomatic.

“We are proud to partner on research that has the potential to leverage a long-term public investment in building the national registry to help cure diseases and improve our ability to avoid future pandemics,” said Martin Maiers, vice president of research at the National Marrow Donor Programme/Be The Match.

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AUTISM: What You Need To Know

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By Silver Yeibake 

Autism, commonly known as Autism Spectrum Disorder (ASD), is a neurodevelopmental disorder that affects communication, social interaction, and behavior. Autism is referred to as a spectrum condition since it can manifest in a variety of symptoms and abilities. While the actual cause of autism is unknown, evidence suggests that genetic and environmental factors interact to influence its development.

The risk factors include a sibling with autism, advanced age of parents, exposure to certain air pollutants and pesticides before birth, extreme prematurity, mothers with diabetes, immune system disorders or obesity, any difficulty with delivery leading to deprivation of oxygen to the baby’s brain, fever during pregnancy, lack of certain vitamins minerals during pregnancy, and certain genetic conditions, such as Down, fragile X, and Rett syndromes.

“Risk factors can not on their own cause a disease. However, they can increase the likelihood of that disease in a person.”

It is important to know that contrary to trending claims online, there is no scientific or medical evidence that vaccines or consumption of sugar are risk factors for autism.

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Autism is defined by difficulties in social interaction and communication. Individuals with autism may struggle to grasp social cues, maintain eye contact, and engage in typical back-and-forth conversations. Some people may also engage in meaningless, repetitive actions, such as hand-flapping or rocking, and have strong interests in specific areas.

It is essential to remember that autism is a lifelong diagnosis, but with early intervention and adequate care, people with autism can live fulfilling lives.
Autism treatment frequently includes behavioral therapy, speech therapy, occupational therapy, and social skills training. Each individual with autism is unique, thus interventions should be tailored to meet their personal needs and strengths.

In spite of the difficulties that autism can cause, many people with autism possess unique talents and abilities. Some people may succeed in fields such as music, art, mathematics, or programming, thus it is important for society to acknowledge and honor the qualities and achievements of people with autism.

In summary, autism is a complicated and diverse disorder that affects individuals in various ways. By raising autism knowledge, understanding, and acceptance, we can build a more inclusive society in which people with autism can thrive and attain their full potential.

Dr. Yeibake, Weriwoyingipre Silver.
Senior Registrar,
Faculty Of Pediatrics,
WACP

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Don Confirms ‘Zobo’ As Antihypertensive Therapy

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The Deputy Vice Chancellor, University of Nigeria Enugu Campus, UNEC, Prof. Daniel Nwachukwu, after research findings and clinical trials in both animals and human, has confirmed that Hibiscus Sabdariffa, popularly called ‘zobo’ drinks, has all the curative potentials as an antihypertensive therapy.

Nwachukwu, who is a Professor of Cardiovascular Physiology in the university, stated that the antihypertensive effectiveness of the Hibiscus Sabdariffa (zobo) was comparable to those of known antihypertensive drugs that are popular in the retail pharmacies, adding that zobo’s availability, cheapness and absence of side effects make it attractive as an alternative therapeutic agent in mind to moderate hypertensive subjects.

He however cautioned that care should be applied to avoid abuse in the consumption of Hibiscus Sabdariffa (zobo), adding that the therapy could interfere with some anti-malaria drugs while its high dose was also reported to have toxic effects on the liver and kidney.

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Nwachukwu’s discoveries were contained his 201st Inaugural Lecture of the University of Nigeria with the topic “The Marriage Between the Cardiovascular System and Hibiscus Sabariffa: Let no One Put Asunder,” delivered at the moot court hall, Law faculty of the University of Nigeria, Enugu campus.

The DVC warned that Hibiscus Sabariffa consumption is not recommended for persons with low blood pressure because of its well established hypotensive action, advising that during combined therapy with antihypertensive drugs, the blood pressure, BP, must be carefully monitored.

He recommended that industrialists and investors should support large scale production of Hibiscus Sabariffa beverage and its distribution to rural communities in Nigeria, particularly since the raw materials (Hibiscus Sabariffa calyx and water) are cheap and readily available.

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According to Nwachukwu, “This lecture is intended to draw the public attention to our research efforts and unveiling the antihypertensive ability of Hibiscus Sabariffa which is called zobo in our common parlance. What we used for our studies was the same concentration as the locally produced zobo, and we found out that it exerted significant antihypertensive ability, in some cases even higher than the antihypertensive drugs and also did combination therapy with other antihypertensive drugs.

“What is significant is that this zobo is within us, it’s very cheap and it does not have any side effects compared to other antihypertensive agents. The raw material is just to buy zobo, prepare it under hygienic conditions, boil water and put it, sieve it and drink. It may have a sour taste but we do not encourage people to add things like pineapple or sugar in order to make it sweet, because once you do that, you are diluting or reducing its antihypertensive effectiveness.

“We have demonstrated it, both in animal studies and in humans. We are the first to do clinical trials, using mild to moderate antihypertensive Nigerians and we found it very useful. Some of the results show that one can actually use it and we equally saw that you can use it to prevent even diabetes from occurring because it reduces the rise in glucose level.”

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Vice Chancellor of the University, Professor Charles Igwe while summarizing the lecture said that the lecture was in three dimensions; one on health grounds, another in academics and the third an economic value.

“Its economic in the sense that we can also begin to use what God has given us to make money. Maybe because God gave us everything in abundance in this country, we don’t recognize the simplest things God gave us in our environment. Therefore, what we are saying is that we should begin to, at all these pure water productions and incorporate zobo production so as to make money out of it.

“The university has made its contribution through our laboratories and it’s now left for the business community and the industries to come and buy into it and start widening it and make it very economic,” Igwe suggested.
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Glaucoma: What You Need To Know

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By Silver Yeibake 

Hi, did you know that Tuesday 12th March, 2024 is world Glaucoma day?Kindly avail yourself of this opportunity to learn about this important health issue as presented below:

Glaucoma is a dangerous eye disorder that damages the optic nerve, causing visual impairment or permanent blindness if not treated.
The optic nerve transmits visual information from the eye to the brain. Damage to this nerve might cause gradual visual loss that is not immediately obvious.

Worldwide, this disease affects 67 million people and contributes 6.7 million of blindness in this population. Glaucoma is the leading cause of blindness in the world.
The total number of cases is expected to increase to 111 million by 2040. Males are slightly more affected than females.

One of the basic causes of glaucoma is an increase in intraocular pressure (pressure within the eyeball), which can eventually damage the optic nerve (the nerve that makes seeing possible). This increase in pressure could be caused by an accumulation of aqueous humor, the fluid that nourishes the eye.

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There are several forms of glaucoma, including open-angle glaucoma, angle-closure glaucoma, normal-tension glaucoma, and secondary glaucoma, each with unique characteristics and treatment choices.

Some of the risk factors for glaucoma include sustained elevation of intraocular pressure, family history of glaucoma, race (African, Asian), short-sightedness, long-sightedness, age over 50, previous eye injury or surgery, hypertension, diabetes mellitus, migraines, and prolonged steroid therapy.

Glaucoma symptoms may not appear until the problem has advanced sufficiently, therefore regular eye checks are essential for early detection. Blurred vision, eye pain, nausea, and light halos are some of the most frequent glaucoma symptoms. However, these symptoms might be mild or readily misinterpreted as other eye problems, emphasizing the significance of regular eye examinations.

Glaucoma treatment tries to reduce intraocular pressure and protect the optic nerve from further damage. This can be accomplished using a variety of approaches, including prescription eye drops, oral medicines, laser therapy, and surgical procedures. Treatment options are determined on the kind and severity of glaucoma, as well as personal characteristics such as overall health and medical history.

To summarize, glaucoma is a serious eye disorder that requires timely diagnosis and treatment to prevent irreversible vision loss. Regular eye examinations, early detection, and commitment to treatment plans are critical for protecting vision and eye health in glaucoma patients.
Thank you.

Dr. Yeibake, Weriwoyingipre Silver, a
Senior Registrar, Faculty Of Pediatrics, West Africa College of Physician (WACP), writes from Yenagoa, Bayelsa State.

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