News

Another HIV Vaccine Trial Fails After Large-scale Study

Published

3 years ago

January 22, 2023

The only vaccine against HIV being tested nearing the completion of testing trials has proved ineffective, its manufacturer has announced.

Known as Mosaico, the trial was the product of a public-private partnership including the US government and the Janssen Pharmaceuticals.

HIV is a virus that gradually attacks the immune system, which is our body’s natural defence against illness. AIDS is a syndrome caused by the HIV virus.

The failure of the latest candidate underscores the challenges of designing a vaccine for HIV.

The announcement posted on the Johnson & Johnson’s website noted that the study’s independent Data and Safety Monitoring Board determined that the regimen was not effective in preventing HIV infection compared to the placebo among study participants.

It also said no safety issues with the vaccine regimen were identified.

In light of the DSMB’s determination, the Mosaico clinical trial will be discontinued, it said.

It noted that participant notifications and further analyses of the data are underway. Throughout the trial, study investigators have ensured that any individuals who contracted HIV received prompt HIV treatment and care.

“We are disappointed with this outcome and stand in solidarity with the people and communities vulnerable to and affected by HIV,” said the Global Therapeutic Area Head, Vaccines, Janssen Research & Development, LLC, Penny Heaton.

“Though there have been significant advances in prevention since the beginning of the global epidemic, 1.5 million people acquired HIV in 2021 alone, underscoring the high unmet need for new options and why we have long worked to tackle this global health challenge.

“We remain steadfast in our commitment to advancing innovation in HIV, and we hope the data from Mosaico will provide insights for future efforts to develop a safe and effective vaccine. We are grateful to our Mosaico partners and the study investigators, staff, and participants.”

Recall that in 2020, the United States National Institutes of Health announced the end of its HVTN 702 clinical trial of an HIV vaccine. While no safety concerns were found during the trial, the independent data and safety monitoring board found that the vaccine was ineffective in preventing HIV transmission.

Also, in 2021, an investigational HIV vaccine tested in the “Imbokodo” clinical trial conducted in sub-Saharan Africa posed no safety concerns but did not provide sufficient protection against HIV infection, according to a primary analysis of the study data.

Meanwhile, Mosaico, a Phase three study of Janssen’s investigational HIV vaccine regimen, began in 2019 and completed vaccinations in October 2022.

The study included approximately 3,900 cisgender men and transgender people who have sex with cisgender men and/or transgender people, who represent groups and populations vulnerable to HIV, at over 50 trial sites in Argentina, Brazil, Italy, Mexico, Peru, Poland, Puerto Rico, Spain, and the United States.

“The study evaluated an investigational vaccine regimen containing a mosaic-based adenovirus serotype 26 vector (Ad26.Mos4.HIV) administered during four vaccination visits over one year. A mix of soluble proteins (Clade C/Mosaic gp140, adjuvanted with aluminum phosphate) was also administered at visits three and four.

“The Mosaico DSMB analysis, based on the data available to date, indicated that the regimen does not protect against HIV and the study is not expected to meet its primary endpoint. No safety issues with the vaccine regimen were identified. In light of this, the study will be discontinued, and further analyses are underway.

“The DSMB’s determination follows the primary analysis of the Phase 2b Imbokodo study, which was announced in August 2021 and found that a similar investigational HIV vaccine regimen did not provide sufficient protection against HIV in a population of young women in sub-Saharan Africa.

“The investigational vaccine regimen used in the Imbokodo study was found to have a favorable safety profile,” it added.

News

Why I Picked Amupitan As INEC Chair – Tinubu

Published

2 hours ago

October 9, 2025

Editor

President Bola Tinubu on Thursday explained that his choice of Professor Joash Amupitan (SAN) as the new Chairman of the Independent National Electoral Commission was based on his apolitical stance, integrity and impeccable record of service.

“President Tinubu told the council that Amupitan is the first person from Kogi, North-Central state, nominated to occupy the position and is apolitical,” a statement by Tinubu’s Special Adviser on Information and Strategy, Bayo Onanuga, quoted him as saying.

The President spoke at the State House, Abuja, during the meeting of the National Council of State, which unanimously endorsed the nomination of Amupitan to succeed Professor Mahmood Yakubu, whose decade-long tenure as INEC Chairman ended on Tuesday.

Tinubu told council members that Amupitan, a professor of law from Kogi State, North-Central Nigeria, is the first person from the state to be nominated for the top electoral job.

Council members, including serving and former leaders, backed the nomination, describing the professor as a man of proven integrity.

Kogi State Governor, Usman Ododo, said Amupitan’s track record “reflects a deep commitment to justice, knowledge, and national service.”

Following the council’s approval, the President is expected to transmit Amupitan’s name to the Senate for screening and confirmation in line with constitutional provisions.

Aged 58, Amupitan hails from Ayetoro Gbede in Ijumu Local Government Area of Kogi State.

A professor of law at the University of Jos, Plateau State, he is currently the institution’s Deputy Vice-Chancellor (Administration) and also serves as the Pro-Chancellor and Chairman of the Governing Council of Joseph Ayo Babalola University in Osun State.

He obtained his Bachelor’s, Master’s, and Doctorate degrees in law from the University of Jos, after earlier studies at the Kwara State Polytechnic, Ilorin.

Called to the Nigerian Bar in 1988, Amupitan has built an extensive academic and administrative career spanning over three decades.

He became a Senior Advocate of Nigeria in 2014 and has written extensively on company law, corporate governance, and evidence law.

His published works include Corporate Governance: Models and Principles (2008), Documentary Evidence in Nigeria (2008), Evidence Law: Theory and Practice in Nigeria (2013), and Principles of Company Law (2013).

Beyond academia, Amupitan has served on several boards, including Integrated Dairies Limited in Vom, the Nigerian Institute of Advanced Legal Studies, and the Council of Legal Education.

He was also a board member of Riss Oil Limited, Abuja, between 1996 and 2004.

The Kogi-born scholar, described by colleagues as “a jurist of quiet influence,” is married with four children.

When confirmed by the Senate, Amupitan will become Nigeria’s 15th INEC chairman.

News

Meet New INEC Chairman, Joash Amupitan

Published

2 hours ago

October 9, 2025

Editor

President Bola Tinubu has nominated Professor Joash Ojo Amupitan, a Senior Advocate of Nigeria, as the new Chairman of the Independent National Electoral Commission.

The appointment, which was confirmed by the National Council of State on Thursday, follows the exit of Professor Mahmood Yakubu from the electoral body.

According to a statement issued by Presidential aide Bayo Onanuga, Amupitan’s nomination marks the first time a native of Kogi State will head Nigeria’s election management agency.

The law professor hails from Ayetoro Gbede in Ijumu Local Government Area of Kogi state.

Amupitan, who currently serves as the Deputy Vice-Chancellor (Administration) at the University of Jos, has spent more than three decades in academia and legal practice.

He joined the institution in 1989 as an Assistant Lecturer and rose through the ranks to become a Reader in 2003 and a Professor of Law in 2008.

Details from the University of Jos website show that the new INEC boss obtained all his degrees, including Bachelor’s, Master’s, and Doctorate, in Law from the same university.

He was called to the Nigerian Bar in 1988 after completing his programme at the Nigerian Law School, Lagos.

Amupitan’s areas of academic and professional interest include Law of Evidence, Corporate Law, Corporate Governance, and Privatisation Law.

He was conferred with the prestigious rank of Senior Advocate of Nigeria (SAN) in 2014 in recognition of his contributions to the legal profession.

Beyond academics, Amupitan has held several administrative and national positions.

He has served as Dean of the Faculty of Law, Head of the Department of Public Law, and Chairman of the Committee of Deans and Directors at the University of Jos.

He has also represented the institution on several boards, including the Council of Legal Education and the Nigerian Institute of Advanced Legal Studies, where he served as a member of the Governing Council.

He was, until his nomination, the Pro-Chancellor and Chairman of Council of Joseph Ayo Babalola University, Osun State.

The legal scholar has authored and co-authored over 50 academic publications, with research spanning corporate governance, electoral law reform, and petroleum industry legislation.

He has supervised more than a dozen doctoral and master’s students in law.

Professor Amupitan is a member of the Nigerian Bar Association, the Nigerian Institute of Management, and the National Association of Law Teachers.

Outside academics, he has served on several boards, including Integrated Dairies Limited, Riss Oil Limited, and the Nigerian Institute of Advanced Legal Studies Governing Council.

He is married to Dr. (Mrs.) Yemisi Amupitan, and they have four children.

News

Elder Statesman Christopher Kolade Dies

Published

2 hours ago

October 9, 2025

Editor

Veteran broadcaster and former Nigerian High Commissioner to the United Kingdom, Dr Christopher Kolade, has died at the age of 92.

The family announced the elder statesman’s death in a statement on Thursday.

The statement said the late former Chairman of Cadbury Nigeria died peacefully on Wednesday, October 8, 2025.

“We are thankful for his incredible life of faith and service, and are grateful for God’s abundant blessings,” the statement read in part.

Kolade had a distinguished career as a diplomat, academic, advocate for integrity and corporate governance, among other things.

Born on December 28, 1932, in Erin-Oke, Osun State, Kolade was the son of an Anglican missionary. He attended Government College, Ibadan, before proceeding to Fourah Bay College in Freetown, Sierra Leone, where he completed his higher education.

Kolade began his career in broadcasting, eventually rising to the position of Director General of the Nigerian Broadcasting Corporation.

He later became Chief Executive and Chairman of Cadbury Nigeria Plc, where he was widely recognised for his ethical leadership and corporate reforms.

The deceased also served Nigeria as High Commissioner to the United Kingdom, leaving behind a legacy of diplomacy, integrity, and professionalism.

Kolade taught Corporate Governance and Human Resources Management at the Lagos Business School and Leadership & Conflict Management at the School of Media & Communication, both part of Pan-Atlantic University, Lagos.

Kolade, a former member of the university’s Governing Council, also served as its Pro-Chancellor and Chairman, and was later Chancellor of McPherson University, Ogun State.

Deeply committed to promoting ethical standards in business, Kolade chaired several integrity-driven organisations, including Integrity Organisation Ltd GTE and The Convention on Business Integrity Ltd GTE.