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Another HIV Vaccine Trial Fails After Large-scale Study

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The only vaccine against HIV being tested nearing the completion of testing trials has proved ineffective, its manufacturer has announced.

Known as Mosaico, the trial was the product of a public-private partnership including the US government and the Janssen Pharmaceuticals.

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HIV is a virus that gradually attacks the immune system, which is our body’s natural defence against illness. AIDS is a syndrome caused by the HIV virus.

The failure of the latest candidate underscores the challenges of designing a vaccine for HIV.

The announcement posted on the Johnson & Johnson’s website noted that the study’s independent Data and Safety Monitoring Board determined that the regimen was not effective in preventing HIV infection compared to the placebo among study participants.

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It also said no safety issues with the vaccine regimen were identified.

In light of the DSMB’s determination, the Mosaico clinical trial will be discontinued, it said.

It noted that participant notifications and further analyses of the data are underway. Throughout the trial, study investigators have ensured that any individuals who contracted HIV received prompt HIV treatment and care.

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READ ALSO: FG Okays Salary Increase For Port Workers

“We are disappointed with this outcome and stand in solidarity with the people and communities vulnerable to and affected by HIV,” said the Global Therapeutic Area Head, Vaccines, Janssen Research & Development, LLC, Penny Heaton.

“Though there have been significant advances in prevention since the beginning of the global epidemic, 1.5 million people acquired HIV in 2021 alone, underscoring the high unmet need for new options and why we have long worked to tackle this global health challenge.

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“We remain steadfast in our commitment to advancing innovation in HIV, and we hope the data from Mosaico will provide insights for future efforts to develop a safe and effective vaccine. We are grateful to our Mosaico partners and the study investigators, staff, and participants.”

Recall that in 2020, the United States National Institutes of Health announced the end of its HVTN 702 clinical trial of an HIV vaccine. While no safety concerns were found during the trial, the independent data and safety monitoring board found that the vaccine was ineffective in preventing HIV transmission.

Also, in 2021, an investigational HIV vaccine tested in the “Imbokodo” clinical trial conducted in sub-Saharan Africa posed no safety concerns but did not provide sufficient protection against HIV infection, according to a primary analysis of the study data.

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Meanwhile, Mosaico, a Phase three study of Janssen’s investigational HIV vaccine regimen, began in 2019 and completed vaccinations in October 2022.

The study included approximately 3,900 cisgender men and transgender people who have sex with cisgender men and/or transgender people, who represent groups and populations vulnerable to HIV, at over 50 trial sites in Argentina, Brazil, Italy, Mexico, Peru, Poland, Puerto Rico, Spain, and the United States.

“The study evaluated an investigational vaccine regimen containing a mosaic-based adenovirus serotype 26 vector (Ad26.Mos4.HIV) administered during four vaccination visits over one year. A mix of soluble proteins (Clade C/Mosaic gp140, adjuvanted with aluminum phosphate) was also administered at visits three and four.

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READ ALSO: WHO To Establish TB Vaccine Accelerator Council

“The Mosaico DSMB analysis, based on the data available to date, indicated that the regimen does not protect against HIV and the study is not expected to meet its primary endpoint. No safety issues with the vaccine regimen were identified. In light of this, the study will be discontinued, and further analyses are underway.

“The DSMB’s determination follows the primary analysis of the Phase 2b Imbokodo study, which was announced in August 2021 and found that a similar investigational HIV vaccine regimen did not provide sufficient protection against HIV in a population of young women in sub-Saharan Africa.

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“The investigational vaccine regimen used in the Imbokodo study was found to have a favorable safety profile,” it added.

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JUST IN: Kenya Airways Pays NCAA Sanction Fee For Passenger’s Rights Violations

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Kenya Airways has paid the sanction fee imposed by the Nigerian Civil Aviation Authority over passenger rights violations, including the case involving Nigerian traveller Gloria Omisore.

According to a post by the Director, Public Affairs and Consumer Protection, Michael Achimugu, on his official X account on Thursday, the airline settled the penalty on Wednesday, September 17, 2025, following a series of meetings that included the Kenyan High Commissioner to Nigeria, airline representatives, and officials from Jomo Kenyatta International Airport.

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Kenya Airways has, on Wednesday 17/09/2025, paid the sanction fee as a penalty for the Gloria Omisore and other consumer protection-related infractions,” Achimugu confirmed.

READ ALSO:NCAA Slams Penalty On Kenya Airways Over Gloria Omisore, Others

He stressed that NCAA sanctions are not designed to punish operators but to strengthen compliance with safety and passenger-handling standards.

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As always, NCAA sanctions are not to punish operators, but to help improve their flight operations, especially with regard to safety and passenger handling protocols,” he said.

While commending Kenya Airways for complying, Achimugu noted that payment of fines does not conclude the matter, as the timeframe for resolving the cases has already elapsed. “The payment of sanction fines does not conclude the issues. The NCAA will follow through and is assuring both passengers and airlines of its commitment to protecting their rights and responsibilities,” he added.

Achimugu also emphasised the airline’s long-standing partnership with Nigeria, noting that the penalty was case-specific and does not diminish the positive aspects of its operations.

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The NCAA said it would continue to enforce regulations to safeguard passenger rights and ensure airlines adhere to international aviation standards.

READ ALSO:NCAA Petitions IGP Over KWAM 1’s Unruly Conduct In Abuja Airport

In February, Nigerian passenger Gloria Omisore accused Kenya Airways of mishandling her during a disrupted trip that left her stranded at Nairobi’s Jomo Kenyatta International Airport. Omisore, who had been denied boarding on her connecting flight to Paris due to a missing Schengen transit visa, claimed the airline had earlier assured her she was eligible to travel. The visa issue resulted in a 17-hour layover, followed by an additional 10-hour delay for an alternative London route offered by the airline.

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During the long wait, Omisore requested accommodation and care, citing exhaustion and health concerns, but Kenya Airways declined, arguing that such provisions do not apply in visa-related denied boardings. The situation escalated into a confrontation, captured on video, where Omisore allegedly threw used sanitary pads at staff.

In response, the NCAA launched an investigation, finding Kenya Airways guilty of breaching consumer protection regulations and misleading the public in its initial statements.

On May 7, 2025, the NCAA sanctioned the airline, ordering compensation of 1,000 Special Drawing Rights for each of the three affected passengers, including Omisore, and demanding a public apology.

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Flood: Residents Chide Edo Govt Over Failure To Show Concern

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Residents of Ekpoma in Esan West Local Government Area of Edo State have lambasted the Governor Monday Okpehbolo-led state government over failure to show concern on the tragic incident where a cocoa merchant, Frank Omoruyi, was swept away by flood.

Recall that it was reported on Tuesday that flood swept away a man earlier identified as motorcyclist.

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The residents, while expressing displeasure over the state government’s failure to send any rescue team to help recover the corpse, said they paid what they termed ‘good money’ to divers from Benue State to recover Omoruyi’s corpse from a burrow pit at Uwenbo area after two days of intense search.

READ ALSO:Okpebholo Warns Companies Against Fuelling Edo–Delta Boundary Dispute

The residents who lamented that no state government or local government official joined in the rescue operation, threatened to protest and stop further construction work of the Benin-Auchi highway.

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A resident, Samuel Osarenkhoe said: “Two Benue boys were hired to get the body out. We paid them handsomely. He was a cocoa merchant. He was our member and a good friend.

Another resident, Luis Ebabulu, said: “They were saddened that no government official visited the community two days after the incident occurred.

READ ALSO:Edo PDP Knocks Okpebholo Over ₦2.5b Donation To UBTH

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No government official has been here since the incident occurred. We have been contributing money to pay people to search for the body. We are coming out tomorrow to protest to stop the project. They cannot be doing roads and be killing us.

“Flooding and erosion problems have been worsened by the construction of the Benin-Auchi highway. The contractor channeled flood water to the borrowed pit.”

Edo State Commissioner for Information and Orientation, Hon. Paul Ohonbamu, said Governor l has desilted drainages across the state.

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Police Disown Viral Recruitment Notice, Warn Against Fraud

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The Nigeria Police Force has disowned a recruitment notice circulating on social media, describing it as fake and warning Nigerians not to fall victim to fraudulent schemes.

The document, titled “Nigeria Police Force Recruitment Exercise 2025”, had invited applications from SSCE, OND, HND, and B.Sc. holders, listing requirements such as age limits, fitness standards, and academic qualifications. It also outlined an alleged application process through a supposed police recruitment portal scheduled to open on September 23, 2025.

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The notice claimed that candidates were expected to be Nigerian citizens by birth, hold a valid National Identification Number, and meet minimum height and academic criteria. It also warned against membership of secret societies and directed applicants to submit various documents, including birth certificates and guarantor declarations.

READ ALSO:Police Vows To Arrest Killers of NSCDC Officers In Edo

In a post on its verified X handle on Thursday, the Nigeria Police Force dismissed the claims and stamped the document “FAKE” to alert the public.

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The Police Service Commission (PSC) had earlier issued a similar warning. On August 30, PSC spokesperson Ikechukwu Ani clarified that no recruitment exercise had been announced for 2025.

The advertorial currently in circulation is fictitious and diversionary,” Ani said. “The Commission has repeatedly urged young Nigerians eager to join the police to be patient and await the official process.”

READ ALSO:Police Vows To Arrest Killers of NSCDC Officers In Edo

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He added that the forged documents being circulated bear no resemblance to the Commission’s official communication.

The police authorities reiterated that any official recruitment exercise would be publicly announced through verified government platforms.

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