News
Another HIV Vaccine Trial Fails After Large-scale Study
Published
3 years agoon
By
Editor
The only vaccine against HIV being tested nearing the completion of testing trials has proved ineffective, its manufacturer has announced.
Known as Mosaico, the trial was the product of a public-private partnership including the US government and the Janssen Pharmaceuticals.
HIV is a virus that gradually attacks the immune system, which is our body’s natural defence against illness. AIDS is a syndrome caused by the HIV virus.
The failure of the latest candidate underscores the challenges of designing a vaccine for HIV.
The announcement posted on the Johnson & Johnson’s website noted that the study’s independent Data and Safety Monitoring Board determined that the regimen was not effective in preventing HIV infection compared to the placebo among study participants.
It also said no safety issues with the vaccine regimen were identified.
In light of the DSMB’s determination, the Mosaico clinical trial will be discontinued, it said.
It noted that participant notifications and further analyses of the data are underway. Throughout the trial, study investigators have ensured that any individuals who contracted HIV received prompt HIV treatment and care.
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“We are disappointed with this outcome and stand in solidarity with the people and communities vulnerable to and affected by HIV,” said the Global Therapeutic Area Head, Vaccines, Janssen Research & Development, LLC, Penny Heaton.
“Though there have been significant advances in prevention since the beginning of the global epidemic, 1.5 million people acquired HIV in 2021 alone, underscoring the high unmet need for new options and why we have long worked to tackle this global health challenge.
“We remain steadfast in our commitment to advancing innovation in HIV, and we hope the data from Mosaico will provide insights for future efforts to develop a safe and effective vaccine. We are grateful to our Mosaico partners and the study investigators, staff, and participants.”
Recall that in 2020, the United States National Institutes of Health announced the end of its HVTN 702 clinical trial of an HIV vaccine. While no safety concerns were found during the trial, the independent data and safety monitoring board found that the vaccine was ineffective in preventing HIV transmission.
Also, in 2021, an investigational HIV vaccine tested in the “Imbokodo” clinical trial conducted in sub-Saharan Africa posed no safety concerns but did not provide sufficient protection against HIV infection, according to a primary analysis of the study data.
Meanwhile, Mosaico, a Phase three study of Janssen’s investigational HIV vaccine regimen, began in 2019 and completed vaccinations in October 2022.
The study included approximately 3,900 cisgender men and transgender people who have sex with cisgender men and/or transgender people, who represent groups and populations vulnerable to HIV, at over 50 trial sites in Argentina, Brazil, Italy, Mexico, Peru, Poland, Puerto Rico, Spain, and the United States.
“The study evaluated an investigational vaccine regimen containing a mosaic-based adenovirus serotype 26 vector (Ad26.Mos4.HIV) administered during four vaccination visits over one year. A mix of soluble proteins (Clade C/Mosaic gp140, adjuvanted with aluminum phosphate) was also administered at visits three and four.
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“The Mosaico DSMB analysis, based on the data available to date, indicated that the regimen does not protect against HIV and the study is not expected to meet its primary endpoint. No safety issues with the vaccine regimen were identified. In light of this, the study will be discontinued, and further analyses are underway.
“The DSMB’s determination follows the primary analysis of the Phase 2b Imbokodo study, which was announced in August 2021 and found that a similar investigational HIV vaccine regimen did not provide sufficient protection against HIV in a population of young women in sub-Saharan Africa.
“The investigational vaccine regimen used in the Imbokodo study was found to have a favorable safety profile,” it added.
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News
Church Of Nigeria Formally Cuts Ties With Wales Over Lesbian Archbishop
Published
59 minutes agoon
August 7, 2025By
Editor
The Church of Nigeria (Anglican Communion) has officially cut all ties with the Church in Wales following the appointment of Bishop Cherry Vann, an openly lesbian cleric, as the 15th Archbishop of Wales.
The decision was announced by the Primate of the Church of Nigeria, the Most Reverend Henry Ndukuba, who described the development as ‘an abomination’ and a serious departure from biblical truth.
The announcement came during the opening session of the 14th Church of Nigeria Conference of Chancellors, Registrars and Legal Officers, held on Tuesday at the Church’s national secretariat in Abuja.
With the theme ‘Called as a Watchman’, the event brought together legal minds from across the Church to discuss matters of doctrinal integrity, justice, and governance.
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Primate Ndukuba delivered the keynote address titled ‘The Decade of the Reign of God: Progress, Challenges, and Prospects.’
Reacting to the Church in Wales’ elevation of a lesbian bishop, the Primate said, “We reject the election of the Right Reverend Cherry Vann as the Archbishop of Wales.”
He compared it to the 2003 consecration of Gene Robinson in the Episcopal Church (USA), which had also led to Nigeria severing ties with that province.
“Just as the Church of Nigeria took steps after the election of Gene Robinson in the United States, we are severing every tie and relationship with the Church of Wales,” he said.
Primate Ndukuba also criticised what he described as the growing influence of revisionist teachings within sections of the Western Church.
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“These individuals have not relented from their evil agenda; rather, they have intensified it. What they call their wisdom and culture is an abomination to God,” he declared.
Despite cutting formal ties with the Church in Wales, the Church of Nigeria reaffirmed its support for orthodox Anglicans in the region through platforms such as the Global Anglican Future Conference (GAFCON).
“We pray that the Church of God in Wales will rise up, and that the faithful among them will stand strong. We, the Church of Nigeria, alongside GAFCON, will stand with them,” Ndukuba assured.
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Looking ahead, the Primate said the Church of Nigeria plans to expand its global mission, with new registrations underway in countries like Germany, the Netherlands, and Finland.
“We feel that the Lord is calling us back to Europe for mission,” he said.
The Primate also used the opportunity to highlight the Church’s ongoing contributions to the GAFCON movement.
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He revealed that the Church of Nigeria had recently contributed $2.5 million to the GAFCON Endowment Fund and was planning a local Nigerian GAFCON Endowment worth $2.3 million to support orthodox Anglican work and mission.
On constitutional and legal matters, Ndukuba urged legal officers to strengthen the Church’s internal reforms and national engagement.
“You are to understand yourselves to be watchmen for the Church. You defend the Church against all forms of aggression. As modern-day watchmen, we must first listen to God, then speak His truth in love, knowing our duty lies in obedience,” he said, calling on legal professionals to support the Church’s constitutional review and advocate for a new Nigerian constitution.
News
EFCC Arraigns Six Katsina Revenue, Bank Workers Over N1.2bn Fraud
Published
2 hours agoon
August 7, 2025By
Editor
The Economic and Financial Crimes Commission, on Tuesday arraigned five officials of the Katsina State Board of Internal Revenue and a staff of First Bank over an alleged N1.2 billion fraud.
The accused were brought before Justice Musa Danladi of the Katsina State High Court by the Commission’s Kano Zonal Directorate on a seven-count charge bordering on conspiracy and diversion of public funds.
According to the anti-graft agency in a statement on Wednesday, the total sum allegedly diverted is N1,235,330,000, said to be tax remittances from the World Health Organization, Médecins Sans Frontières, and the Alliance for International Medical Action, which were due to the Katsina State Government.
The defendants, Nura Lawal, Sanusi Mohammed Yaro, Ibrahim Mamman, Abubakar Saidu, Rabiu Adamu Abdullahi, and Adam Alhassan Albashir, a Public Sector Relationship Manager with First Bank, were all docked and pleaded not guilty to the charges.
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One of the charges reads:
“That you Nura Lawal, Sanusi Mohammed Yaro, Ibrahim Mamman, Abubakar Saidu, Rabiu Adamu Abdullahi and Adam Alhassan Albashir between January, 2022 to August, 2024 at Katsina within the jurisdiction of the Katsina State High Court, being staff of Board of Internal Revenue Services (BOIRS), Katsina and Public Sector Relationship Manager of First Bank, in such capacity conspired among yourselves to commit an unlawful act to wit: unlawfully converted to your personal uses the tax payments meant for the Katsina State Government and you thereby committed an offence contrary to Section 58 of the Penal Code Law of Katsina State and punishable under Section 298 of the Same Law.”
After their plea, prosecution counsel Musa Isah urged the court to fix a trial date to enable the Commission prove its case.
However, the defence counsels filed separate bail applications for the six defendants, requesting their release pending trial. Isah opposed the applications.
Justice Danladi, after listening to both sides, granted bail to each defendant in the sum of N5m with one reliable surety resident within the court’s jurisdiction.
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The Judge said surety must possess verifiable landed property, with the title documents to be verified by the court registrar.
The case was adjourned to October 27, 2025, for the commencement of trial.
According to EFCC investigations, Rabiu Abdullahi, a former Director of Collections and current Permanent Secretary of the Board, allegedly authorised the opening of an account named “BOIRS” with Sterling Bank. Sanusi Mohammed Yaro and Ibrahim Mamman were appointed as the sole signatories.
The commission said the account became the main channel for funnelling the diverted funds to NADIKKO General Suppliers, a company allegedly owned and controlled by Nura Lawal, an Assistant Director in the Career Skills/Staff Welfare unit of the Board.
EFCC findings also showed that NADIKKO and Lawal served as key conduits in laundering the proceeds, which were traced to multiple bank accounts linked to the suspects.
News
FG Urges Nigerians Abroad To Register With Embassies For Emergency Support
Published
2 hours agoon
August 7, 2025By
Editor
The Federal Government has called on Nigerians travelling abroad to register with Nigerian embassies and consulates in their host countries to enable timely intervention during emergencies.
The appeal was made by the Permanent Secretary of the Ministry of Foreign Affairs, Ambassador Dunoma Ahmed, during a meeting with the Diplomatic Correspondents Association of Nigeria, led by its Chairman, Idehai Frederick, at the Ministry’s headquarters in Abuja on Wednesday.
According to DICAN, Amb. Ahmed stressed the importance of informing Nigerian missions upon arrival in foreign countries, rather than waiting until problems arise.
“I advise Nigerians to make it a point of duty to make their presence known to the Nigerian mission in the country they’re visiting.
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“This simple step can help prevent misunderstandings and ensure that Nigerians receive the support they need in times of crisis.
“There was a recent case of Nigerians trapped in the Central African Republic, where some Nigerians tried to give the Ministry a bad name,” he said.
The Permanent Secretary highlighted the role of timely and accurate information in managing crises and emphasised the need for closer collaboration with media organisations like DICAN to combat misinformation.
“Most of the time, giving the necessary information before they even ask for information is crucial in managing crises effectively.
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“We are saddled with the role of laundering the image of the country. Hence, the inevitability of a strengthened partnership between DICAN and the Ministry,” Perm. Sec. noted.
He underscored the significance of disseminating accurate narratives about Nigeria’s foreign policy, particularly in the face of growing disinformation.
Ambassador Ahmed also commended DICAN for hosting the maiden Diplomatic and Security International Conference, which brought together about 70 diplomats, security experts, academics, and representatives of civil society to discuss strategies for global safety and peace.
In appreciation of the Ministry’s cooperation, DICAN Chairman said, “The Permanent Secretary has shown commitment to working with DICAN, and we appreciate his efforts in promoting a positive image of Nigeria.”
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