News

Another HIV Vaccine Trial Fails After Large-scale Study

Published

3 years ago

January 22, 2023

The only vaccine against HIV being tested nearing the completion of testing trials has proved ineffective, its manufacturer has announced.

Known as Mosaico, the trial was the product of a public-private partnership including the US government and the Janssen Pharmaceuticals.

HIV is a virus that gradually attacks the immune system, which is our body’s natural defence against illness. AIDS is a syndrome caused by the HIV virus.

The failure of the latest candidate underscores the challenges of designing a vaccine for HIV.

The announcement posted on the Johnson & Johnson’s website noted that the study’s independent Data and Safety Monitoring Board determined that the regimen was not effective in preventing HIV infection compared to the placebo among study participants.

It also said no safety issues with the vaccine regimen were identified.

In light of the DSMB’s determination, the Mosaico clinical trial will be discontinued, it said.

It noted that participant notifications and further analyses of the data are underway. Throughout the trial, study investigators have ensured that any individuals who contracted HIV received prompt HIV treatment and care.

“We are disappointed with this outcome and stand in solidarity with the people and communities vulnerable to and affected by HIV,” said the Global Therapeutic Area Head, Vaccines, Janssen Research & Development, LLC, Penny Heaton.

“Though there have been significant advances in prevention since the beginning of the global epidemic, 1.5 million people acquired HIV in 2021 alone, underscoring the high unmet need for new options and why we have long worked to tackle this global health challenge.

“We remain steadfast in our commitment to advancing innovation in HIV, and we hope the data from Mosaico will provide insights for future efforts to develop a safe and effective vaccine. We are grateful to our Mosaico partners and the study investigators, staff, and participants.”

Recall that in 2020, the United States National Institutes of Health announced the end of its HVTN 702 clinical trial of an HIV vaccine. While no safety concerns were found during the trial, the independent data and safety monitoring board found that the vaccine was ineffective in preventing HIV transmission.

Also, in 2021, an investigational HIV vaccine tested in the “Imbokodo” clinical trial conducted in sub-Saharan Africa posed no safety concerns but did not provide sufficient protection against HIV infection, according to a primary analysis of the study data.

Meanwhile, Mosaico, a Phase three study of Janssen’s investigational HIV vaccine regimen, began in 2019 and completed vaccinations in October 2022.

The study included approximately 3,900 cisgender men and transgender people who have sex with cisgender men and/or transgender people, who represent groups and populations vulnerable to HIV, at over 50 trial sites in Argentina, Brazil, Italy, Mexico, Peru, Poland, Puerto Rico, Spain, and the United States.

“The study evaluated an investigational vaccine regimen containing a mosaic-based adenovirus serotype 26 vector (Ad26.Mos4.HIV) administered during four vaccination visits over one year. A mix of soluble proteins (Clade C/Mosaic gp140, adjuvanted with aluminum phosphate) was also administered at visits three and four.

“The Mosaico DSMB analysis, based on the data available to date, indicated that the regimen does not protect against HIV and the study is not expected to meet its primary endpoint. No safety issues with the vaccine regimen were identified. In light of this, the study will be discontinued, and further analyses are underway.

“The DSMB’s determination follows the primary analysis of the Phase 2b Imbokodo study, which was announced in August 2021 and found that a similar investigational HIV vaccine regimen did not provide sufficient protection against HIV in a population of young women in sub-Saharan Africa.

“The investigational vaccine regimen used in the Imbokodo study was found to have a favorable safety profile,” it added.

News

Grassroots To Global Podium: Edo Sports Commission Marks Enabulele’s First Year In Office

Published

4 hours ago

December 19, 2025

Editor

The Indoor Sports Hall in Benin City came alive on Wednesday as the Edo State Sports Commission rolled out the drums to celebrate the first anniversary in office of its Executive Chairman, Hon. Amadin Desmond Enabulele. Management, staff, coaches and athletes gathered in an atmosphere charged with pride, reflection and optimism.

The colourful ceremony drew executives and members of various sports associations, officials of the Sports Writers Association of Nigeria (SWAN), coaches, athletes and other key stakeholders in Edo sports.

In her welcome address, the Acting Permanent Secretary of the Commission, Mrs. A. P. Amenze, praised Hon. Enabulele for what she described as focused and purposeful leadership. She said the past year had seen renewed confidence, discipline and energy return to the state’s sports ecosystem.

Adding excitement to the event were exhibition bouts and demonstrations by the Kung Fu, Karate, Taekwondo and Judo associations, staged in honour of the Executive Chairman.

Speaking for SWAN Edo State, Chairman Comrade Kehinde Osagiede commended Hon. Enabulele’s open-door leadership style and consistent support for sports development. He noted that the Commission had effectively driven Governor Monday Okpebholo’s “Catch Them Young” policy through practical grassroots programmes that identify and groom young talents across the state.

In recognition of his contributions to sports development and media relations, Comrade Osagiede conferred the Patronship of SWAN Edo State on Hon. Enabulele and presented him with a special anniversary card.

Goodwill messages followed from Executive Directors of the Commission, including Hon. Frank Ilaboya (Edo North), Coach Baldwin Bazuaye, MON (Edo South), Barr. Anthony Ikuenobe (Edo Central), and Mrs. Sabrina Chikere, Executive Director, Sports Development and Operations. Representatives of coaches, athletes and sports associations also took turns to acknowledge the progress recorded under the current leadership.

In his stewardship address, Hon. Enabulele expressed gratitude to Governor Monday Okpebholo and Deputy Governor Rt. Hon. Dennis Idahosa for the trust placed in him, noting that their backing and shared vision had driven the Commission’s achievements.

He highlighted Team Edo’s third-place finish at the 9th National Youth Games in Asaba, where the state recorded its best-ever outing with 79 medals—33 gold, 18 silver and 28 bronze—reinforcing Edo’s reputation as a national sports powerhouse.

The Chairman also pointed to the impact of inclusive and grassroots sports programmes, citing Favour Ojeabu, a visually impaired para-cyclist who won three gold medals to emerge Africa’s champion at the African Track Para-Cycling Championship in Egypt.

Other milestones listed included outstanding performances by Edo para powerlifters on the international stage, historic achievements in cricket, weightlifting, cycling, judo and deaf athletics, as well as structural reforms such as the repositioning of Bendel Insurance FC and deeper investment in grassroots sports development.

Cultural performances added colour and tradition to the celebration, as stakeholders closed the event united in their assessment of the past year as a truly transformative period for sports development in Edo State.

News

Otuaro Tasks Media On Objective Reportage

Published

12 hours ago

December 18, 2025

Editor

The Administrator, Presidential Amnesty Programme (PAP) Dr. Dennis Otuaro has charged media practitioners particularly members of the Ijaw Publishers’ Forum to promote ethical journalism through their reportage.

He gave the charge in Warri on Wednesday during the 2nd Annual Ijaw Media Conference organised by the Ijaw Publishers’ Forum (IPF).

Represented by Princewill Binebai, spokesman, Ijaw Youth Council (IYC) Worldwide, Otuaro while stating that the Niger Delta stories have been told in such a way that is quite different from what is obtainable in the real sense, said this, IPF must do everything possible to correct.

The administrator added: “I am happy that Ijaw journalists have boldly come out together to champion the Ijaw struggle in a very dynamic perspective”.

“The Ijaw story was misrepresented over the years, but IPF’s emergence had corrected this error and the story is gradually changing for better.”

Otuaro, however, challenged Ijaw media practitioners to be objective, truthful, accurate and fearless in their reportage to correct many years anomalies of the Ijaw struggle.

He admonished members of IPF to see themselves as brothers and love one another in the discharge of their activities to achieve a common goal.

News

Police Confirm Edo Tanker Explosion, say No Casualty

Published

12 hours ago

December 18, 2025

Editor

The Edo State Police Command has confirmed tanker explosions that rocked Auchi, the administrative headquarters of Etsako West Local Government Area of the state.

The Command’s Police Publice Relations Officer, Eno Ikoedem, who confirmed the incident via the phone, said the explosion occurred at about 6:30 p.m. following the fall of a fuel tanker along the road.

Ikoedem said the incident occurred on Wednesday evening at about 6:30 p.m. following the fall of a fuel tanker along the road.

She explained that spilled fuel seeped into underground tunnels, which later ignited and caused three explosions in different parts of the Auchi community.

According to her, officers from the Auchi Divisional Police Headquarters and the Area Command were mobilised to the affected areas and successfully cordoned them off to prevent loss of lives.

She added: “No casualty was recorded. Our men on ground were able to cordoned the affected areas.”

It was gathered that three separate explosions rocked the town simultaneously in different parts, which led to properties worth millions of naira destroyed.

A resident who does not want his name in print said via the telephone that the blasts occurred along Igbei Road, Igbo Shade, and along the Auchi–Okene Road, close to Winners Junction.

The resident, who alleged the explosions appeared to have been coordinated, called for a thorough investigation into the incident to prevent future occurrences.

Calls put across to Mr. Monday Edogiawere, Chairman, Red Cross, Edo State, were not picked.