News
Another HIV Vaccine Trial Fails After Large-scale Study
Published
3 years agoon
By
Editor
The only vaccine against HIV being tested nearing the completion of testing trials has proved ineffective, its manufacturer has announced.
Known as Mosaico, the trial was the product of a public-private partnership including the US government and the Janssen Pharmaceuticals.
HIV is a virus that gradually attacks the immune system, which is our body’s natural defence against illness. AIDS is a syndrome caused by the HIV virus.
The failure of the latest candidate underscores the challenges of designing a vaccine for HIV.
The announcement posted on the Johnson & Johnson’s website noted that the study’s independent Data and Safety Monitoring Board determined that the regimen was not effective in preventing HIV infection compared to the placebo among study participants.
It also said no safety issues with the vaccine regimen were identified.
In light of the DSMB’s determination, the Mosaico clinical trial will be discontinued, it said.
It noted that participant notifications and further analyses of the data are underway. Throughout the trial, study investigators have ensured that any individuals who contracted HIV received prompt HIV treatment and care.
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“We are disappointed with this outcome and stand in solidarity with the people and communities vulnerable to and affected by HIV,” said the Global Therapeutic Area Head, Vaccines, Janssen Research & Development, LLC, Penny Heaton.
“Though there have been significant advances in prevention since the beginning of the global epidemic, 1.5 million people acquired HIV in 2021 alone, underscoring the high unmet need for new options and why we have long worked to tackle this global health challenge.
“We remain steadfast in our commitment to advancing innovation in HIV, and we hope the data from Mosaico will provide insights for future efforts to develop a safe and effective vaccine. We are grateful to our Mosaico partners and the study investigators, staff, and participants.”
Recall that in 2020, the United States National Institutes of Health announced the end of its HVTN 702 clinical trial of an HIV vaccine. While no safety concerns were found during the trial, the independent data and safety monitoring board found that the vaccine was ineffective in preventing HIV transmission.
Also, in 2021, an investigational HIV vaccine tested in the “Imbokodo” clinical trial conducted in sub-Saharan Africa posed no safety concerns but did not provide sufficient protection against HIV infection, according to a primary analysis of the study data.
Meanwhile, Mosaico, a Phase three study of Janssen’s investigational HIV vaccine regimen, began in 2019 and completed vaccinations in October 2022.
The study included approximately 3,900 cisgender men and transgender people who have sex with cisgender men and/or transgender people, who represent groups and populations vulnerable to HIV, at over 50 trial sites in Argentina, Brazil, Italy, Mexico, Peru, Poland, Puerto Rico, Spain, and the United States.
“The study evaluated an investigational vaccine regimen containing a mosaic-based adenovirus serotype 26 vector (Ad26.Mos4.HIV) administered during four vaccination visits over one year. A mix of soluble proteins (Clade C/Mosaic gp140, adjuvanted with aluminum phosphate) was also administered at visits three and four.
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“The Mosaico DSMB analysis, based on the data available to date, indicated that the regimen does not protect against HIV and the study is not expected to meet its primary endpoint. No safety issues with the vaccine regimen were identified. In light of this, the study will be discontinued, and further analyses are underway.
“The DSMB’s determination follows the primary analysis of the Phase 2b Imbokodo study, which was announced in August 2021 and found that a similar investigational HIV vaccine regimen did not provide sufficient protection against HIV in a population of young women in sub-Saharan Africa.
“The investigational vaccine regimen used in the Imbokodo study was found to have a favorable safety profile,” it added.
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News
INEC CVR: CSO Expresses Worry Over Poor Deployment Of Machines, Manpower To LGs In Edo
Published
2 hours agoon
August 29, 2025By
Editor
By Joseph Ebi Kanjo
Edo Civil Society Organisations (EDOCSO) has expressed worry over the poor deployment of capturing machines and manpower to Igueben Local Government Area of the state by the Independent National Electoral Commission (INEC) in the ongoing Ongoing Continuous Voters Registration (CVR).
The Coordinator, EDOCSO, Igueben Study Centre, Leftist Enabulele Larry, and Secretary, Leftist Mark Akande expressed the CSO sentiment when the duo visited the INEC headquarters in Igueben where the CBR in the local government is taking place.
In a statement made available to INFO DAILY on Friday, the leadership of EDOCSO, Igueben Study Centre condemned the “use of only two capturing devices in a local government with over 69, 396 in population.”
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The duo noted in the statement that their findings at the INEC headquarters revealed two capturing machines were deployed to each local government across the 18 local government areas of the state.
The civil society members said INEC excuse of deploying two capturing machines to each local government was not germane enough because many do not have a computer or android phone to do the online registration INEC gave as an excuse.
“The question here is, what is the percentage of our people mostly the aged individuals, that have access to Android mobile and other internet gadgets in Edo state?
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“How many people can afford internet data to enable them have access internet services in Edo state under the current excruciating economic pains by the people?
“How many of the Edo people can even manipulate the Android mobile phone to the extent of navigating the internet hurdles to undertake the job is INEC? If INEC is not ready for the job, they should tell Nigerians.
“If citizens are now advised to individually undertake the statutory job of INEC, of what purpose does the commission serve to the people? etc,” they said.
As at when filing this report, INFO DAILY was yet to get a reply from the message sent to the INEC in Edo for reaction.
News
Edo Sports Commission Boss Celebrates Okpehbolo On Birthday
Published
7 hours agoon
August 29, 2025By
Editor
The Executive Chairman of the Edo State Sports Commission, Hon. Amadin Desmond Enabulele, has felicated with Governor Monday Okpebholo, on the occasion of his birthday.
In a statement issued on Friday by his Media Officer, Edoko Wilson Edoko, Enabulele Okpebholo as a visionary leader whose dedication to the growth and development of the state has continued to inspire confidence and admiration across all sectors, especially sports.
Enabulele, who highlighted the governor’s unwavering commitment to youth empowerment through sports development, noted that under his leadership, Edo State has witnessed significant strides in grassroots sporting initiatives and infrastructure.
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“His Excellency, Senator Monday Okpebholo, is not just a political leader but a beacon of hope for the younger generation.
“His passion for excellence and inclusive governance is evident in the way he has continued to support policies that uplift our youths and promote sporting excellence,” the statement read.
The Executive Chairman prayed for long life, good health, and continued wisdom for the governor as he steers the affairs of the state towards greater prosperity.
“On behalf of the entire Edo State Sports Commission, I extend our warmest birthday wishes to His Excellency at 55. May this new chapter of his life be filled with more accomplishments and divine grace,” he added.

The Oba of Benin, Ewuare II, has suspended two of his chiefs for falling for dereliction of duties.
This was contained in a statement signed by the Secretary to the Benin Traditional Council (BTC), Frank Irabor and made available to journalists in Benin City.
He said their suspension was as a result of their long absence from the palace, resulting in their failure to carry out their palace responsibilities.
The suspended persons are: Chief John Igiehon, the Izuwako of Benin and chief Aimiukpomonyako Oghogho (Ebengho), the Oyenmwensoba of Benin.
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“The under-mentioned two (2) chiefs have been suspended from the Palace of the Oba of Benin.
“This is as a result of their long absence from the Palace, resulting in their failure to carry out their Palace responsibilities.
“The public is advised to be wary of unscrupulous chiefs that are no longer functioning in the Palace. His Royal Majesty has approved their _ Suspension and directed the public be duly informed.
“The names of the chiefs are: – ; 1. CHIEF JOHN IGIEHON, THE IZUWAKO OF BENIN and, _ 2 CHIEF AIMIUKPOMONYAKO OGHOGHO (EBENGHO), THE OYENMWENSOBA OF BENIN”, the statement said.
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