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OPINION: Obasa, Aláàfin Ṣàngó And The Capture Of Lagos

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By Festus Adedayo

On Wednesday, February 25, 2025, a very toxic but innocuous advertorial was published in the Punch newspaper. It was authored by a group which called itself De Renaissance Patriots Foundation. Entitled Systematic Marginalization of Lagos State Indigenes, and signed by Major General Tajudeen Olanrewaju (rtd.) and Yomi Tokosi, the advertorial explains the legislative gangsterism currently going on in Lagos State, ex-Speaker Mudashiru Obasa’s impudent audacity and President Bola Tinubu’s nauseating silence on the civilian coup ongoing in the State of Aquatic Splendour.

The only fitting narrative that can explain the Obasa phenomenon and the Lagos godfather’s paternalism for Obasa and his ilk is the Osu caste system in Igboland. Among other obnoxious systems like the killing of twin babies, killing of children who grew first upper incisors, human sacrifices, among others, Osu caste is evergreen in its evil, and rooted in Igbo tradition and religion. Rev. George Thomas Basden’s book Among the Ibos of Southern Nigeria, (1921), a detailed account of the clergy’s experiences while living in Igbo land as a Christian missionary in the early 20th century, examines the people’s customs, beliefs, social structure and religious practices.

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On page 109 of the book, Basden defined Osu as “a slave, but one distinct from an ordinary slave (ohu/oru) who in fact is the property of the god and when devoted to a god, he has no prospect of regaining freedom and he restricts his movements to the procuts of the shrine to which he was attached”. Centuries after the end of slavery and in spite of modernity, Osu caste’s poignant smell is rank in Igboland as Osu are still discriminated against, cannot marry a freeborn, their aspirations curtailed. They are thus forced to form an inter-group bond and alliance to press for their rights. A former minister under Olusegun Obasanjo, who is an Osu, is the rallying point of this caste against discrimination by “freeborn” Igbo. As I will argue presently, the Lagos parliament crisis, among other indicators, is fueled by the ancient indigene/settler dichotomy in Lagos. In this case, the Lagos godfather symbolizes the Obasanjo minister, hell-bent on protecting his fellow Lagos migrant-settlers.

General Olanrenwaju’s group which published the advertorial made several allegations against the godfather. They are encapsulated in the phrase, “persistent discrimination against the indigenous people of Lagos State.” Perhaps, the most insulting to the group was the temerity of the godfather’s choice of two non-indigenes of the state, Bisi Akande and Segun Osoba, ex-governors of Osun and Ogun States, to mediate in the crisis of the Lagos House of Assembly. Apart from the group’s total denunciation of this alien intervention, it specifically took Akande to the cleaners. Akande, it said, who “is struggling for political breath” in his home state, being unable to resolve the ongoing conflagration therein, feels entitled to poke-nose into Lagos matter “because his children, Akande Funmilayo (Chairman Apapa/Iganmu LCDA) and Yinka Akande are seriously benefiting from (sic) as Local Council Chairman and Director of Lekki Free Trade Zone respectively.”

As groups or individuals, Lagos indigenes have always stood up against the ruling establishment. A 1908 proposed water rate for Lagosians is an example. On July 20 of that year, Governor Walter Egerton proposed to charge Lagosians for them to access portable water. This was after his government constructed a #130,000 pipe borne water scheme, the precursor of the Iju waterworks built in 1916. Two indigenes of Lagos, John Randle and Orisadipe Obasa, medical doctors, under the banner of the People’s Union, arranged a rally of Lagosians at Enu Owa on November 26, 1908 where they took Egerton on. Randle and Obasa were themselves not autochthonous Lagosians. Randle, born in 1855 in Regent, Sierra Leone, originally from Oyo town, was son of Thomas, who settled in Aroloya part of Lagos, while Obasa, whose father descended from the Elekole of Ikole-Ekiti, was brought to Lagos in 1878. It must be borne in mind that Orisadipe Obasa has no ancestral connect with Mudashiru who is currently recreating an MC Oluomo motor-park hijack prototype in the Lagos parliament.

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Indigene/settlers conflict in Lagos dates back to the 15th century. The Awori headsmen earliest settlers on Lagos Island, descendants of legendary Ogunfunminire, who hailed from Ile-Ife, had faced a Bini attempt to uproot them which was successful. A fierce battle that took place at Iddo had Olofin, who administered the area, being routed. Since then, the development of Lagos has attracted the influx of migrant-settlers Yoruba and other ethnicities laying claim to Lagos. The influence of migrant-settlers was so overwhelming that when in 1950, Dr I. Olorun-Nimbe emerged Mayor of the Lagos Council, only him and four others were Lagos indigenes while the rest 19 were migrant-settlers. The 1951 Constitution which placed Lagos under Ibadan, in a Western Region administration, further worsened Lagos’ fate, until the 1954 Constitution restored its place. In 1967, Lagos got a state of its own and federal capital status. So, when in the 1950s, the heartland of Lagos indigenes’ residence, the Isale Eko, was demolished, groups were formed to continually fight the interest of indigenous Lagosians. They included the Isale Eko Association (1955) and Egbe Eko Parapo (Lagos Citizens’ Rights Protection Council – LCRPC) 1962. The latter emerged from a merger of the Lagos Aborigines Society and the Egbe Omo Ibile Eko (Association of the Sons of Lagos State) which was led by Chief T. A. Doherty. Today, the most prominent of those associations is the Association of Lagos State Indigenes (ALSI) hitherto led by Justice Ishola Oluwa, a retired High Court Judge.

The role of identity in Nigeria’s migrant-settlers crisis shows its importance in Nigerian social life. It also shows that identity has negative potentials that can be deployed as a tool for mobilizing violence. In the year 2000, Lagos deployed identity for violence when Hausa and Yoruba indigene-settlers engaged one other in a fratricidal war in Ketu. That fight, which claimed lives, indicates the adversarial use that autocththony can be put to. Scholars have said that several of Nigeria’s worst conflicts occurred because original inhabitants, or indigenes, are pitted against migrant-settlers. The Obasa Lagos budding conflict, though appears political, may unravel the powers behind it.

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In Yorubaland, the migrant-settlers dynamics is rich in literature. It is indeed an ancient phenomenon. Signified by the native markers of àjèjì or àjòjì (migrants) and onílé, (autocththony) the common phrase that defines that transaction is, no migrant-settler should duel with an indigene over ownership of land (àjòjì kìí b’ónílé du’lé). This is the meat of General Olanrewaju and his De Renaissance Patriots Foundation’s beef with Tinubu and why many autochthonous Lagosians, regardless of Tinubu’s behemoth political power in Nigeria, his talismanic influence and boundless wealth, are against his continued domination of Lagos. It also explains why a Tinubu, who today is carrying a monstrous elephant of Nigerian power and wealth on his head could be this needlessly bothered by the tiny cricket of being sidelined in the sack of Obasa as Lagos House of Assembly Speaker. The moment Tinubu loses this makeshift, badly-constructed Lagos identity in the battle with autochthonous Lagosians, he has lost all.

The above was recalled with the aim of stating that, though the àjèjì and onílée stranger politics in Lagos has always been on the front burner, it has been more pronounced in recent time. This specifically drew more Lagosians’ ire with the godfather, an àjèjì, becoming the Lord of Lagos and defender of the rights of fellow migrant settlers. In the above referenced advertorial, the De Renaissance Patriots Foundation claimed that since 1999, only one Lagos Omo-Onílé (son of the land) has been governor, ostensibly Raji Fashola. What this means is that Tinubu, Akinwumi Ambode and Babajide Sanwo-Olu, in the words of the advertorial, are àjòjì. The group also listed names of many àjòjì who it said have, unfairly, hoisted the banner of Lagos at the detriment of Lagosians.

Some extreme ones among the Lagos indigenes’ rights advocates have literally equalized their battle to an ancient Yoruba wise saying that no stranger can back a child like its mother (kò s’éni t’ó le mòó pòn bí olómo). Some others, in pursuit of this narrative, have claimed that the àjòjì at the helm of political affairs in and of Lagos, don’t appreciate Lagos enough, just like the domestic goat undervalues the prowess of a hunter and his gun; or one who inherits a huge agbada gown does not appreciate its value (ewúrẹ́ ilé kó mọ iyì odẹ, aj’ogún ẹwù kó mọ iyì agbádá nlá). It is on these twin premises that they derive their two conclusions. One is that, Lagos could have developed more than it does if the migrant-settlers had been autochtonous Lagosians. Second, that Lagos could have been greater but for the fact that the wealth accruable to the Ajoji from their leadership of Lagos are being funneled to the migrants’ original place of migration.

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Prior to 1999, there did not seem to be anyone who held the jugular of Lagos like Tinubu. Before the ascendancy of his volcanic phenomenon, the last power outpost of Lagos was a group pejoratively called the ‘Ijebu Mafia’, disciples of Chief Obafemi Awolowo, operating as Afenifere leaders, living in Lagos. They determined the political geography of the aquatic state. Indeed, this group conducted the primary for the 1999 governorship which allegedly had Late Funsho Williams coming tops but which an internal abracadabra among the group tilted in favour of Tinubu. Immediately he grabbed political power, Tinubu, applying Law 33 of Robert Greene’s 48 Laws of Power which encourages the power holder to discover each man’s thumbscrew – their weaknesses – found out the Ijebu Mafia leaders’ thumbscrew and used it to prepare their political graveyards. He then succeeded in tearing them apart, deploying the Niccolo Machiavelli divide and rule tactics in the service of his ambition.

By 2007 when the godfather left office as Lagos governor, he had totally decimated their ranks, cloning a counter-group called Afenifere Renewal Group and leaving the Awo disciples licking their fatally bruised wounds. Abetted by Lagosians themselves, only a few, like the late Chief Ganiyu Dawodu, fought Tinubu to the hilt before his transition. By the time Lagos aborigines woke up to do a reconnaissance, it was too late. The godfather had captured Lagos and kept the lagoon and the sea inside his limitless-space pocket. Twenty five years after, not only does the godfather determine the political and economic barometer of Lagos, he determines when it will rain in the state or its time of drought.

MORE FROM THE AUTHOR: OPINION: Bisi Akande, Poverty And Ige’s Death

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The godfather’s migrant-settler place in Lagos is discussed only in hushed tones. Those privy to his migration and the story of his settling in Lagos maintain sealed lips. While he was governor of Lagos State, some dissident groups made efforts to document his migrancy by writing a book to document the family tree of Lagos Tinubus. Some other analysts have said that if the Lagos autochthony is to be broken into brass-tacks, virtually all Lagosians will fail the litmus test. For instance, the ancestor of the Tinubus is himself a Kanuri. While some settlers chose the Lagos Island side of Lagos called Isale Eko, Sierra Leone returnees were known as Akus or Saros, and Brazilians and Cuban returnees known as Agudas. Many of them originally hailed from towns scattered round the southwest. Only the Aworis can be said to own the Lagos autochthony. Immediately Mudashiru Obasa began to recreate the MC Oluomo-style tactic in Lagos House of Assembly, some forces came out to assert the deposed Speaker’s àt’òhúnrìnwá (migrant) status in Lagos and that he was not linked in any way with Orisadipe Obasa.

The 2023 election witnessed a groundswell of push-backs by, especially non-Yoruba indigene-settlers in Lagos, against the godfather’s fiefdom hold on Lagos. The outcome of that election showed a gradual whittling of the corrosive hold of the godfather on Lagos politics. Apparently a rebellion, Lagos migrant-settlers encircled the Peter Obi Labour Party and succeeded in giving it 582,454 votes as against 572,606 for the godfather’s APC. The godfather must have been furious. Until then and since 1999 when he held court, no one dared peer naked fire to look at the fiery face of the leopard. In the process of scapegoating for this colossal rout, a source told me the godfather held his Ajélè (an appointed official who oversees an empire’s economic and political interests) responsible and has since not forgiven him. More importantly, he is cross with him for being his own man and having the guts to win re-election due to his personal effort. For any godfather, a la the precepts of the Forty-eight Laws of Power, the Ajélè had committed an unpardonable sin against the Leviathan. So, even though Obasa rode roughshod on the Ajélè as Speaker, especially during the 2025 budget speech presentation, keeping him waiting for hours, the godfather wasn’t fazed and probably wrote the script. The world has since seen that, as Obasa’s water bug (Ìròmi) dances on the stream surface with impunity and audacity, executed with sheer brigandage, as well as abetted by institutions of the Nigerian state, the danceable tune egging the poor little creature on comes from a godfather drummer living in Aso Rock whose ego was fatally bruised.

To buttress General Olanrewaju’s submission, today, Lagos political power echelon, from governor, deputy governor, commissioners to special advisers, ministers representing Lagos, to federal and state parliamentarians, is tilted in favour of àt’òhúnrìnwá (immigrants) as against autochthonous Lagosians. The most laughable was Senator Solomon Olamilekan Adeola who represented Lagos West from 2015 to 2023 and before then, from 2011 to 2015, was Lagos House of Representatives member. Today, the man, known as Yayi, has perfunctorily exchanged state of origin like a prostitute changes her liaisons. He now represents Ogun West.

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The story of Lagos, its godfather and potential explosion is beginning to resemble the cataclysmic end of the Yoruba deity of thunder and lightning, Ṣàngó. Aláàfin Ṣàngó, the third monarch of the Oyo Empire, was about the most celebrated and one of the most controversial rulers of the Empire. He was fiery, ambitious, charismatic and was extremely powerful. Like the cap insignia with which the Lagos godfather is known by today and which his worshippers scramble to don, Ṣàngó’s motif was a staff called Ose Ṣàngó, an ornately carved symbol depicted by fire, lighting and thunder.

Ṣàngó, the third Aláàfin of Oyo, who reigned between the 15th and early 16th centuries, was a man of great ambition, fiery charisma, and immense power. His name is invoked today to reify awesome might and the mystery of power. He mirrors a complex interplay of leadership acumen, divinity, and eventually, a reference point of potential human vulnerability. Like the Lagos godfather, Aláàfin Ṣàngó had a talismanic and commanding presence and inspired widespread loyalty. He also had the magical and mystical ability to command fire from the sky in his fit of anger. Ultimately, though his strength , the endowment ultimately led to his downfall. One day, Ṣàngó, enraged, invoked fire which resulted in a conflagration that went out of control. It eventually led to the destruction of his palace as well as lives of its inhabitants. It was the beginning of his end. Stripped of all he had, Ṣàngó departed Oyo Kingdom and never returned. He eventually committed suicide at a place called Koso.

Apart from the power of Yoruba anecdotal retelling latent in that Sango narrative, the downfall of Oba Ṣàngó is a detailed illustration that even in a modern world, no ruler or godfather is immune from the vulnerabilities of power. It also illustrates the destruction immanent in human nature. The Obasa episode, though seemingly miniature, has the potential to implode and flush the Lagos godfather down the drain, replicating the Ṣàngó downfall in recent history.

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Maybe we all should just watch while an end comes to this tyrannical hold, after all, in the words of Nawal El Saadawi in her A daughter of Isis, “Things that never end are only boring, and were it not for death, life would be an impossible burden.”

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The Nigerian Senate erupted again last week. This time, it was not about allegation of its leadership being a cesspool of sleaze, a home of self-serving parliamentarians nor corruptible budget-padding that have become a boring refrain. Sequel to an earlier seemingly infantile squabble over sitting arrangement, the female anti-hero of that row, Natasha Akpoti-Uduaghan, came on air on Friday to allege that her continuous spats with Senate President Godswill Akpabio were due to a sexual harassment she rebuffed in the past. And the social space went bonkers.

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First, the two issues that threw Akpoti-Uduaghan and Senate President Godswill Akpabio to centers of discourse have throwbacks to and possess symbolic bearing in American and biblical history. Many have berated her on why a trifling matter of space/seat allocation on the floor of the parliament should get her that worked up. They must however have forgotten that one of the issues that women who try to square up to men in a patriarchal society like ours face and fight is visibility. While in pursuit of the male dominance thesis, men try to hold women down, such women try to assert themselves and create visibility for themselves.

Akpoti-Uduaghan’s squabble over seating arrangement and Akpabio’s senate’s resistance and insistence on maintenance of status-quo remind me of the famous Montgomery bus altercation of 1955. On December 1 of that year in Montgomery, Alabama, a 42-year-old woman named Rosa Parks did what philosophers call against method. Paul Feyeraband, an Austrian philosopher, had in 1976 pioneered that thesis. In a racial American society of the time where blacks were inferior and expected to leave their bus seats for whites, Parks refused to give up hers for a white male passenger. Her refusal sparked off a boycott that changed the paradigm of racial relationship in America. It even shot the less-known Martin Luther King Jr to world recognition. At the risk of sanctions for her impudence, Parks had reportedly told the Montgomery bus driver, “My feet are tired.” Like Parks’ fight for the visibility of the black race, Akpoti-Uduaghan’s resistance was a fight for the visibility of women.

If other women in the senate like Ireti Kingibe had seen the fight as being beyond mere seat allocation into an underscore of their womanliness and fight against the irritant male-dominated status-quo, they probably would have given the Kogi senator more collective push. Like Bettina Aptheker wrote in her Foreword to Nawal El Saadawi’s A daughter of Isis, “women (daily) struggle for voice and human dignity and to overcome the binds of patriarchy…and are crushed under patriarchal conventions”. Women’s sexuality is constantly crushed in this struggle.

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The second issue that flows from the first is Akpoti-Uduaghan’s allegation of sexual harassment. People have taken stands either on account of their stomachs, what lies between their thighs or their political affiliations. Again, the allegation is a symbolism. Many who cannot stand Akpoti-Uduaghan’s femininity or her boldness to underscore it in a patriarchal senate have likened her allegation to the biblical Portiphar’s wife who alleged that Joseph wanted to sexually assault her. Many have also brought out her alleged history which they claim feeds the trope of her usual allegations of blackmail against the male gender. If allegation is a typecast, Akpabio’s alleged history with women validates Akpoti-Uduaghan’s allegation. A couple of years ago, Joy Nunieh, a former NDDC MD, had alleged that she slapped the senate president when he attempted to sexualize her in his guest house at Apo, Abuja.

On an Arise News interview, Ireti had attempted to infantilize Akpoti-Uduaghan, the same way a huge percentage of the senate fatherlize Akpabio who is only first among equals in the parliament. This is due to the huge war-chest in the possession of his leadership and capability to substantially jerk up members’ personal finance through graft. The other day on the same television station, Peter Onyeka Nwebonyi, representing Ebonyi State, did this by claiming that Akpabio was “our father.” Last Friday, Kingibe did this, too by referring to Akpoti-Uduaghan as “my daughter”. She further fell into the argumentative pitfall of claiming that since Akpabio never assaulted her and the two other female senators, Akpoti-Uduaghan’s allegation must be concocted. I pray thee, do these elderly women still possess their colleague’s sultry disposition? And, isn’t it a rarity to see lascivious flesh-devouring vultures attempt to take grandmothers for supper?

We cannot suffer on all fronts by having a National Assembly that is allegedly a cesspit of Nigerian national patrimony-devourers, as well as home for devourers of the flesh of our women. Yes, it is almost an impossibility to prove sexual harassment by a woman, but Akpoti-Uduaghan’s boldness and the sheaves of evidence she claimed to possess to buttress her claim should be encouraged. No one must attempt a “family affair” settlement or else, one more rascally libido would be let loose.

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Edo Targets 2.2 Million Children For Measles, Rubella Vaccination

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The Edo State Government says it is targeting about 2.2 million children aged between 0 and 14 years for measles and rubella vaccination across the state.

The Director of Disease Control and Immunization at the Edo State Primary Health Care Development Agency, Dr. Eseigbe Efeomon, who disclosed this during stakeholders’ sensitisation meeting in Benin City, said this would be done in collaboration with development partners.

Efeomon, while noting that the vaccination exercise scheduled to hold simultaneously from January 20 to January 30, 2026, across the 18 local government areas of Edo State at designated health facilities and temporary vaccination posts, said the campaign aims to contribute significantly to the reduction of measles and rubella in Nigeria.

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He explained that achieving this target requires increased population immunity through sustained vaccination.

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Dr. Efeomon stressed that only qualified and certified health workers would be recruited as vaccinators because the vaccines are injectable.

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According to him, the vaccination strategy would involve fixed posts and temporary fixed posts, and vaccination cards would be issued to all vaccinated children as proof, which parents and caregivers are advised to keep for future reference.

He added that vaccination teams would visit schools, churches, mosques, markets, motor parks, internally displaced persons’ camps and other public places, while children who receive the vaccine would be finger-marked to prevent double vaccination.

He reiterated that the overarching goal of the campaign is to drastically reduce rubella incidence nationwide and protect children from preventable diseases through effective immunisation coverage.

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Also speaking, the World Health Organization Local Government Facilitator, Mr. Ajaero Paul, described measles and rubella as major causes of death and congenital abnormalities among children globally.

He said both diseases are preventable through the measles-rubella vaccine, which he described as safe and effective,

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He added that sustained advocacy is critical to reducing child mortality and lifelong disabilities.

On his part, UNICEF Social and Behavioural Change Health Officer, Yakubu Suleiman, emphasised that the measles-rubella vaccine is safe and effective for all children aged nine months to 14 years.

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He stated that the government has fully paid for the vaccines, making them available at no cost to all eligible children in government health facilities across the state.

Suleiman explained that vaccination not only protects individual children but also safeguards communities from deadly vaccine-preventable diseases such as measles and rubella.

He added that even children who had previously received the measles vaccine should still be given the measles-rubella vaccine and appealed to schools and other key stakeholders to support the campaign to ensure that no child is left behind.

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Togo, Niger, Benin Owe Nigeria Over $17.8m For Supplied Electricity – NERC

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Nigeria’s electricity regulator has disclosed that three neighbouring countries, Togo, Niger and Benin, are indebted to Nigeria to the tune of $17.8 million, equivalent to more than N25 billion at prevailing exchange rates, for power supplied under bilateral electricity agreements.

The Nigerian Electricity Regulatory Commission, NERC, made this known in its Third Quarter 2025 report, which reviewed market performance within the Nigerian Electricity Supply Industry, NESI.

According to the report, the international customers were billed a total of $18.69 million by the Market Operator for electricity supplied during the third quarter of 2025. However, only $7.125 million was paid, leaving an unpaid balance of $11.56 million for the period under review.

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NERC also revealed that the same international offtakers had outstanding legacy debts amounting to $14.7 million from previous quarters. Of this amount, $7.84 million was settled, leaving a residual balance of $6.23 million.

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When combined with the Q3 2025 shortfall, the total outstanding debt stood at $17.8 million, which translates to about N25.36 billion at an exchange rate of N1,425 to one US dollar.

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The regulator identified the international electricity customers as Compagnie Énergie Électrique du Togo, Société Béninoise d’Énergie Électrique of Benin Republic, and Société Nigérienne d’Électricité of Niger Republic.

NERC stated that the three utilities collectively paid just $7.125 million against the $18.69 million invoice issued for electricity supplied in the third quarter, resulting in a remittance performance of 38.09 per cent.

This meant that more than half of the billed amount remained unpaid at the close of the quarter.

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The commission explained that the electricity exported to the three countries was generated by grid-connected Nigerian generation companies and delivered through cross-border bilateral power supply arrangements.

By contrast, NERC reported a stronger payment performance among domestic bilateral customers. According to the report, local customers paid N3.19 billion out of the N3.64 billion invoiced for the same quarter, representing a remittance rate of 87.61 per cent.

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The regulator further noted that some bilateral customers, both international and domestic, made additional payments to offset outstanding invoices from earlier quarters.

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Specifically, the Market Operator received $7.84 million from international customers and N1.3 billion from domestic customers in settlement of previous obligations.

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Beyond bilateral transactions, NERC disclosed that Nigeria’s 11 electricity distribution companies remitted a total of N381.29 billion to the Nigerian Bulk Electricity Trading Plc and the Market Operator in the third quarter of 2025. This was out of a cumulative invoice of N400.48 billion, translating to an overall remittance performance of 95.21 per cent.

The commission said the figures were derived from reconciled market settlement data submitted as of December 18, 2025, as part of its statutory evaluation of the commercial health and performance of the electricity market.

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Expert Identify Foods That Increase Hypertension Medication’s Effectiveness

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Hypertension remains one of the leading causes of premature death worldwide, contributing significantly to heart disease, stroke, and kidney failure. Despite the availability of effective antihypertensive drugs, long-term control of high blood pressure is often challenging because of drug resistance, side effects, and poor adherence.

This has fueled growing scientific interest in complementary strategies that can enhance drug efficacy while minimising toxicity. One promising approach is the combination of conventional antihypertensive medications with herbs and spices in many kitchens.

Recent evidence suggests that augmenting modern antihypertensive drugs with foods rich in p-coumaric acid, a naturally occurring phenolic acid, may offer a novel and effective strategy for blood pressure control.

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Phenolic compounds, commonly found in fruits, vegetables, whole grains, and legumes, are known for their antioxidant, anti-inflammatory, and blood vessel–protective properties.

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In a study, researchers investigated the combined effects of lisinopril, a widely used antihypertensive drugs and p-coumaric acid on hypertension.

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They reported in the Comparative Clinical Pathology that p-coumaric acid enhance the antihypertensive action of lisinopril, potentially allowing for improved blood pressure control without increasing drug dosage.

The study used an established animal model in which hypertension was induced in rats through oral administration of L-NAME, a compound known to suppress nitric oxide production and raise blood pressure.

Following the induction of hypertension, the animals were treated for 14 days with p-coumaric acid (at two different doses), lisinopril alone, or a combination of both.

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Untreated hypertensive rats showed significantly elevated activities of key enzymes linked to high blood pressure such as ACE, arginase, acetylcholinesterase, and phosphodiesterase-5 along with increased lipid peroxidation, an indicator of oxidative stress. At the same time, levels of nitric oxide, a critical molecule for blood vessel relaxation, were markedly reduced.

By contrast, rats treated with a combination of lisinopril and p-coumaric acid experienced notable improvements. Blood pressure was better controlled; harmful enzyme activities were reduced, oxidative stress declined, and nitric oxide levels increased. These improvements were mirrored in the tissues the heart compared with untreated hypertensive animals.

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They said that the findings suggest that p-coumaric acid may enhance the antihypertensive action of lisinopril, potentially allowing for improved blood pressure control without increasing drug dosage.

This drug–food interaction model is particularly important in the circumstance of long-term hypertension management. Many patients rely on lifelong medication, and strategies that can improve treatment outcomes while reducing side effects are highly desirable.

READ ALSO:Delta Unveils Free Hypertension, Diabetes Screening

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The study also reinforces the growing recognition that diet is not merely supportive but can be biologically active in disease control.

The use of medicinal plants and plant-based therapies in the management of hypertension is deeply rooted in traditional medicine across many cultures. While such practices have often existed outside conventional healthcare systems, modern scientific research is now providing evidence-based explanations for their effectiveness.

While these findings are based on animal studies and cannot yet be directly translated into clinical recommendations for humans, they open the door to future research on dietary strategies that can safely complement antihypertensive drugs.

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Further clinical studies are needed to determine appropriate dosages, safety profiles, and real-world effectiveness.

In the fight against hypertension, the future may lie not only in new drugs, but also in smarter combinations, where medicine and nutrition work together to deliver better, safer outcomes for patients.

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Such nutrition to help maintain healthy blood pressure includes garlic, potatoes, walnuts,tomato and tomato products, legumes and citrus fruits (grapefruits and oranges).
(TRIBUNE)

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