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Scientists Find Proof That Breast Cancer Recurrence Can Be Eliminated

Published

14 hours ago

September 6, 2025

In a medical breakthrough that could transform breast cancer care, scientists at the University of Pennsylvania have shown it’s possible to detect and destroy the “sleeper” cells that cause the disease to return years after treatment.

In a landmark clinical trial, researchers used existing, repurposed drugs to eliminate these hidden cells in most breast cancer survivors, pushing survival rates above 90 per cent. The findings, published in Nature Medicine, offer the strongest proof yet that breast cancer recurrence may no longer be inevitable.

The principal investigator, Dr Angela DeMichele of Penn’s Perelman School of Medicine, said, “The lingering fear of cancer returning is something that haunts many breast cancer survivors. Our study shows that by targeting dormant tumour cells, we can prevent recurrence—and give survivors a real chance at a lasting cure.

“This changes the game. We finally have a proactive strategy—not just waiting for cancer to come back, but stopping it before it does,” DeMichele said.

The trial, known as CLEVER, enrolled 51 breast cancer survivors who had completed treatment but still harboured microscopic traces of dormant tumour cells, also called minimal residual disease (MRD). Standard scans cannot detect these cells, which can “wake up” years later and fuel incurable metastatic cancer.

Patients received either one or two study drugs, both already FDA-approved for other conditions. The results stunned researchers. Dormant tumour cells were cleared in 80 per cent of participants, and the three-year survival without recurrence exceeded 90 per cent for patients on single therapy and reached 100 per cent for those on combination therapy.

Further, only two patients have relapsed after more than three years of follow-up.

“This sleeper phase is the window where cancer is most vulnerable. explained senior author Dr Lewis Chodosh, chair of Cancer Biology at Penn. Surprisingly, drugs that don’t work against active tumours can be highly effective against dormant cells. That’s the key—we’re hitting cancer while it’s asleep,” explained senior author Dr Lewis Chodosh, chair of Cancer Biology at Penn. The trial builds on decades of Penn research uncovering how dormant breast cancer cells survive in the body, sometimes for decades, and what biological pathways sustain them. By targeting autophagy and mTOR signalling—mechanisms that help the sleeper cells persist—the researchers found a way to wipe them out before they reactivate.

The implications are profound. Until now, breast cancer survivors at risk of recurrence had little more than “watch and wait”. For the 30 per cent of patients whose cancer returns, the disease has been incurable.

The Penn team is now preparing larger clinical trials to confirm the results and explore whether this approach can be applied to other cancers with similar dormant-cell behaviour.

For millions of breast cancer survivors worldwide, the research opens the door to a future where remission means freedom—not fear.

Delayed breakfast linked to early death for elderly

How late you eat breakfast could be more important than you think. A major new study has revealed that older adults who push their first meal of the day to later hours face a higher risk of illness and even early death.

The research, published in Communications Medicine by scientists at Mass General Brigham and collaborators in Turkey, tracked nearly 3,000 people in the UK for more than two decades. The results were clear: as people age, breakfast and dinner times creep later, but those who delay breakfast are more likely to suffer from depression, fatigue, poor sleep, and declining health, and they die sooner.

“Breakfast timing may be an easy-to-monitor marker of health in older adults,” said lead researcher Hassan Dashti, PhD, RD, of Massachusetts General Hospital.

“Our findings show that late breakfasts are tied not only to health challenges but also to higher mortality. This gives fresh meaning to the saying that breakfast is the most important meal of the day.”

The team found that people genetically inclined to be “night owls” also tended to eat later, compounding risks as they aged. Meanwhile, those who stuck to consistent and earlier meal routines showed signs of healthier ageing and greater longevity.

The findings could spark a rethink of popular diet trends such as intermittent fasting, which often encourages delaying the first meal. While the approach may benefit younger adults, the study suggests it could be harmful for seniors.

For doctors, families, and carers, the message is simple: watch the clock. A later breakfast may be more than just a habit – it could be a warning sign.
(VANGUARD)

News

W’Cup Qualifiers: Super Eagles Edge Rwanda 1-0 To Revive Qualification Hopes

Published

7 hours ago

September 6, 2025

Editor

In a high-stakes 2026 FIFA World Cup qualifier at the Godswill Akpabio International Stadium in Uyo, Nigeria secured a vital 1–0 victory over Rwanda, breathing new life into their qualification hopes.

The only goal of the match came in the 51st minute when Tolu Arokodare capitalized on a loose ball in the penalty area, slotting it past Rwanda’s goalkeeper to give Nigeria a crucial lead.

The first half ended goalless, with both teams cautious in their approach. Nigeria’s defense, marshalled by Calvin Bassey, held firm despite Rwanda’s tactical shifts in the second half.

News

NCDC Alerts Nigeria As DR Congo Declares Ebola Outbreak

Published

7 hours ago

September 6, 2025

Editor

The Nigeria Centre for Disease Control and Prevention (NCDC) has issued a public health advisory following the confirmation of a new Ebola Virus Disease (EVD) outbreak in the Democratic Republic of Congo (DRC).

As of September 4, 2025, the DRC has reported 28 suspected cases and 15 deaths, including four health workers, in the Kasai Province.

The Director-General of NCDC, Dr. Jide Idris, said the agency will continue to monitor the regional and global situations as there are no cases of Ebola virus disease in Nigeria, as of now.

However, the NCDC is taking proactive measures to prevent the spread of the disease, and it is working closely with relevant Ministries, Departments, Agencies, and Partners to strengthen preparedness and response measures in Nigeria.

Idris urged Nigerians to practice good hand hygiene by washing their hands regularly with soap under running water or using hand sanitisers. He also advised Nigerians to avoid physical contact with anyone showing symptoms of infection or an unknown diagnosis.

Additionally, individuals should handle animals with gloves and protective clothing, and cook animal products thoroughly to reduce the risk of wildlife-to-human transmission.

Furthermore, people should avoid direct contact with the blood, saliva, vomit, urine, and other bodily fluids of suspected or confirmed EVD cases.

The NCDC advises Nigerian citizens and residents to avoid all but essential travel to countries with confirmed Ebola cases. Those with recent travel history to affected areas who experience symptoms should promptly call the NCDC hotline (6232) or their State Ministry of Health hotline for assessment and testing.

They should also shelter-in-place to avoid further spread through shared transport systems and await dedicated responders for assessment and possible transport to a treatment centre.

The NCDC is strengthening surveillance across the country, including borders and airports, and enhancing laboratory capacities for quick testing of suspected cases.

Idris assured that the agency will continue to provide periodic updates on the situation as the Ebola outbreak in the DRC is caused by the Zaire strain, with a mortality rate estimated at 57%.

The World Health Organisation (WHO) has deployed experts to support response efforts, and the DRC has activated its Public Health Emergency Operations Centre.

News

5% Fuel Surcharge: What Nigerians Should Know

Published

7 hours ago

September 6, 2025

Editor

File Copy: Chairman of the Presidential Committee on Tax Policy and Fiscal Reforms, Taiwo Oyedele

Confusion has erupted online over a supposed 5% fuel surcharge under Nigeria’s new tax laws, with many fearing a sudden increase in fuel prices.

The chairman of the Presidential Committee on Fiscal Policy and Tax Reforms, Taiwo Oyedele, on Saturday through a post on X, clarified what is fact and what is fiction.

The controversy arises from the recent passage of the Nigeria Tax Act, 2025, which consolidates and harmonises previous tax laws.

Some social media posts suggested that President Bola Tinubu’s administration had introduced a new surcharge on fuel, sparking public concern.

Oyedele clarified: “The charge is not a new tax introduced by the current administration. The provision already exists under the Federal Roads Maintenance Agency (Amendment) Act, 2007. Its restatement in the new Tax Act is for harmonisation and transparency rather than immediate implementation.”

According to Oyedele, the surcharge is meant to fund road infrastructure, an area that has historically suffered from underfunding.

Over the years, Nigeria’s road network has faced chronic maintenance challenges, resulting in potholes, travel delays, and higher vehicle operating costs.

Oyedele further noted that the surcharge is intended to create a dedicated, predictable funding source for road construction and maintenance.

Oyedele addressed key questions raised by citizens:

Will the surcharge start automatically in January 2026?

No. It will only take effect when the Minister of Finance issues an order published in the Official Gazette:

“The surcharge does not take effect automatically with the new tax laws. It will only commence when the Minister of Finance issues an order published in the Official Gazette as stated under Chapter 7 of the Nigeria Tax Act, 2025. This safeguard ensures careful consideration of timing and economic conditions before implementation,” Oyedele stated.

Does it apply to all fuels?

No. Household energy products such as kerosene, LPG, and CNG are exempt. Clean and renewable energy products are also excluded to support Nigeria’s energy transition agenda.

Why maintain the surcharge amid economic hardship?

Oyedele explained that the fund is meant as a dedicated mechanism for road maintenance:

He said, “The surcharge is designed as a dedicated fund for road infrastructure and maintenance. If implemented effectively, it will provide safer travel conditions, reduce travel time and cost, lower logistics costs and vehicle maintenance expenses, which will benefit the wider economy. This practice is virtually universal with over 150 countries imposing various charges ranging between 20% to 80% of fuel products to guarantee regular investment in road infrastructure.”

Could subsidy savings cover road funding instead?

The Chairman of theCommittee on Fiscal Policy and Tax Reforms said: “While subsidy savings will provide some funding, they are insufficient to meet Nigeria’s huge and recurring road infrastructure needs among other public finance needs. A dedicated fund ensures reliable and predictable financing for roads, complementing the budget and ensuring roads are not left underfunded.”

Does this contradict the tax reform objective of easing citizens’ burden?

Oyedele reassured: “The reforms have already reduced multiple taxes and removed or suspended several charges that directly affect households and small businesses, such as VAT on fuel, excise tax on telecoms, and the cybersecurity levy. By harmonising earmarked taxes, government is reducing duplication and ensuring a more efficient tax system.”

Why not remove the surcharge entirely?

He clarified: “Yes, the surcharge has been removed from the FERMA Act and incorporated into the new tax laws which are designed to provide a forward-looking legal framework for Nigeria. Keeping this provision in place within a harmonised legal framework ensures Nigeria is prepared to address critical challenges, such as sustainable road financing and even climate change impacts. It is not about immediate implementation, but to ensure the law provides a clear and effective framework for when it becomes necessary in the future.”

In summary, Oyedele stressed that the surcharge is not new, not immediate, and selectively applied. Its inclusion in the law is about transparency, preparedness, and sustainable funding for Nigeria’s roads, and it aims to address long-standing gaps in infrastructure financing.
(PUNCH)